Evidence map›Paper›PMID 40737301›Full record

ReviewCancer reports (Hoboken, N.J.)2025

The Role of PIWI-Interacting RNA in Urologic Carcinoma and Its Clinical Implications.

Jiajia Cai, Shirui Jiang, Dongdong Lu, Ghulam Murtaza, Mingbang Wang, Yuqing Li, Da Shi, Yingrui Li, Hu Fang, Song Wu

Abstract readReview
In one paragraph

Review in Cancer reports (Hoboken, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jiajia CaiDepartment of Experimental Research, South China Hospital, Medical School, Shenzhen University, Shenzhen, China.ORCID 0009-0008-9301-2292
Shirui JiangDepartment of Experimental Research, South China Hospital, Medical School, Shenzhen University, Shenzhen, China.ORCID 0000-0002-3324-7785
Dongdong LuDepartment of Experimental Research, South China Hospital, Medical School, Shenzhen University, Shenzhen, China.ORCID 0000-0002-7940-0941
Ghulam MurtazaDepartment of Experimental Research, South China Hospital, Medical School, Shenzhen University, Shenzhen, China.ORCID 0000-0002-6371-8701
Mingbang WangDepartment of Experimental Research, South China Hospital, Medical School, Shenzhen University, Shenzhen, China.ORCID 0000-0002-5989-5377
Yuqing LiDepartment of Experimental Research, South China Hospital, Medical School, Shenzhen University, Shenzhen, China.ORCID 0000-0002-9018-8195
Da ShiDepartment of Experimental Research, South China Hospital, Medical School, Shenzhen University, Shenzhen, China.ORCID 0009-0006-4649-1943
Yingrui LiDepartment of Experimental Research, South China Hospital, Medical School, Shenzhen University, Shenzhen, China.ORCID 0000-0001-6630-1277
Hu FangDepartment of Experimental Research, South China Hospital, Medical School, Shenzhen University, Shenzhen, China.ORCID 0000-0003-3092-6034
Song WuDepartment of Experimental Research, South China Hospital, Medical School, Shenzhen University, Shenzhen, China.ORCID 0000-0003-3504-1630

Funding

Development and Reform Commission of Shenzhen Municipality XMHT20220104016National Natural Science Foundation of China 61931024National Natural Science Foundation of China 82203196National Natural Science Foundation of China 92359202Sanming Project of Medicine in Shenzen Municipality SZSM202211009Shenzhen Science and Technology Innovation Program RCJC20200714114557005 and JCYJ20220818100015031Shenzhen Science and Technology Program JCYJ20230807141009020
6 · The paper itself

Abstract

Piwi-interacting RNA (piRNA) represents a class of small non-coding RNA molecules, typically ranging in length from 18 to 35 nucleotides. These molecules are critically involved in the preservation of genomic integrity and the regulation of protein translation processes. Recently, emerging scholarly research indicates that piRNA exhibits tissue-specific expression profiles within a variety of human malignancies, where they intricately regulate key signaling pathways at both the transcriptional and post-transcriptional levels. This review systematically underscores current investigations pertaining to piRNA in urologic carcinoma (UC), elucidating the proposed regulatory mechanisms encompassing N6-methyladenosine (m6A) modification and the silencing of transposable elements. Furthermore, we discuss the detection technology and the application of piRNA in the fields of clinical diagnosis.

Indexed as

Biomarkers, TumorRNA, Small InterferingUrologic NeoplasmsAdenosineDNA Transposable ElementsGene Expression Regulation, NeoplasticHumansPiwi-Interacting RNAAdenosineBiomarkers, TumorDNA Transposable ElementsN-methyladenosinePiwi-Interacting RNARNA, Small Interferingclinical implicationPIWI‐interacting RNAurologic carcinoma

Identifiers

PMID40737301
PMCPMC12309732

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.