Evidence map›Paper›PMID 40737294›Full record

ArticleMolecular biology of the cell2025

Rab14 promotes Parkin-mediated mitophagy.

Samina Momtaz, Marco Padilla-Rodriguez, Paola Cruz Flores, Natalia Rulli, Nam Yong Lee, Jean M Wilson

Abstract read
In one paragraph

Article in Molecular biology of the cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Rab12 is a regulator of mitophagy and mitochondrial homeostasis.bioRxiv : the preprint server for biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Samina MomtazDepartment of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ 85724.
Marco Padilla-RodriguezMicroscopy Shared Resource, The University of Arizona Cancer Center, University of Arizona, Tucson, AZ 85724.
Paola Cruz FloresDepartment of Chemistry and Biochemistry, University of Arizona, Tucson, AZ 85724.
Natalia RulliMacalester College, Saint Paul, MN 55105.
Nam Yong LeeDepartment of Chemistry and Biochemistry, University of Arizona, Tucson, AZ 85724.
Jean M WilsonDepartment of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ 85724.

Funding

VITAMIN AP30CA023074 · NCI · UNIVERSITY OF ARIZONA · PI Dan Theodorescu · 1985 to 2026
$110.2M
Autophagy and LC3-associated phagocytosis in intestinal epithelial cellsR01DK132074 · NIDDK · UNIVERSITY OF ARIZONA · PI Jean M Wilson · 2022 to 2026
$2.2M
Endocytic Regulation of Intestinal DevelopmentR01DK109701 · NIDDK · UNIVERSITY OF ARIZONA · PI WILSON, JEAN M · 2017 to 2021
$2.1M
TGF-beta signaling in mitochondrial dynamicsR35GM148171 · NIGMS · UNIVERSITY OF ARIZONA · PI Nam Y Lee · 2023 to 2026
$1.5M
NCI NIH HHS P30 CA023074NIDDK NIH HHS R01 DK109701NIDDK NIH HHS R01 DK132074NIGMS NIH HHS R35 GM148171
6 · The paper itself

Abstract

Mitochondrial degradation by mitophagy is essential to maintain cell metabolism; dysregulation can result in the accumulation of damaged mitochondria. Although the Rab family of small GTPase proteins are involved with vesicular trafficking in the endocytic and biosynthetic pathways, Rab-GTPases also have a role in mitochondrial integrity. However, a role for Rab14, a

Indexed as

Mitophagyrab GTP-Binding ProteinsUbiquitin-Protein LigasesHeLa CellsHumansMitochondriaMitochondrial ProteinsPhosphatidylinositol 3-KinasesProtein Serine-Threonine Kinasestrans-Golgi NetworkMitochondrial Proteinsparkin proteinPhosphatidylinositol 3-KinasesProtein Serine-Threonine KinasesRab14 protein, humanrab GTP-Binding ProteinsTBK1 protein, humanUbiquitin-Protein Ligases

Identifiers

PMID40737294
PMCPMC12415616

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.