Evidence map›Paper›PMID 40737134›Full record

ArticleMicrobial genomics2025

Temporal characterization of the gut microbiome and metabolome in preterm infants.

Lauren C Beck, Thomas Sproat, Christopher A Lamb, Andrew Filby, David McDonald, Andrea C Masi, Gregory R Young, Sophie Hambleton, Nicholas D Embleton, Christopher J Stewart and 1 more

Abstract read
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Article in Microbial genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lauren C BeckTranslational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.
Thomas SproatNewcastle Neonatal Service, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, NE1 4LP, UK.
Christopher A LambTranslational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.
Andrew FilbyBiosciences Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.
David McDonaldBiosciences Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.
Andrea C MasiTranslational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.
Gregory R YoungTranslational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.
Sophie HambletonTranslational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.
Nicholas D EmbletonNewcastle Neonatal Service, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, NE1 4LP, UK.
Christopher J StewartTranslational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.
Janet E BerringtonTranslational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.

Funding

Wellcome Trust
6 · The paper itself

Abstract

Preterm infants experience abnormal microbial colonization, which coupled with their vulnerable physiology can increase the risk of disease. Understanding the factors influencing the complex relationship between the temporal development of the gut microbiome and functional metabolites derived from microbe-microbe and microbe-host interaction is therefore critical. In this study, 266 longitudinal stool samples from 66 very preterm infants underwent 16S rRNA gene sequencing to analyse gut microbial structure. To further explore the functional status of these gut members, a subset of these samples underwent stool metabolomics (

Indexed as

BacteriaGastrointestinal MicrobiomeInfant, PrematureMetabolomeFecesFemaleHumansInfant, NewbornMaleMetabolomicsRNA, Ribosomal, 16SRNA, Ribosomal, 16Sinfantmetabolomemicrobiomepreterm

Identifiers

PMID40737134
PMCPMC12310240

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.