ReviewDiscover oncology2025
The complex role and molecular mechanism of family with sequence similarity genes in cancer: a comprehensive review.
Review in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Article
- Estrogen-Mediated Regulation of Fam3d in Mouse Uterus During the Estrous Cycle.International journal of molecular sciences · 2025Article
- The Emerging Role of FAM171A2 in Gynecological Malignancies: Bioinformatic Insights from UCEC and Ovarian Cancer.International journal of molecular sciences · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The family with sequence similarity (FAM) is a family of genes with unknown functions and similar sequences. However, recent studies have reported that many FAM members play important roles in the onset and progression of cancer. Specifically, the expression of this type of gene is abnormal in tissues and cells of different types of cancer and is related to the prognosis of cancer patients. In addition, their expression regulates the proliferation, migration, invasion, epithelial-mesenchymal transition (EMT), and drug resistance of different types of cancer cells. Some members even show dual and contradictory effects in tumor-promoting or suppressing cancer. In this review, we summarized the role of FAM members in various solid tumors and sorted out the regulatory mechanism of FAM involved in tumor signal transduction, confirming their role as an important node in tumor signal transduction. Their potential as tumor markers and therapeutic targets was highlighted, offering new insights for cancer research.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.