Evidence map›Paper›PMID 40736930›Full record

ArticleJournal of cancer survivorship : research and practice2026

The relationship between allostatic load levels and time to deterioration of health-related quality of life in non-small cell lung cancer patients.

Xi Chen, Jinman Zhuang, Zishan Chen, Shiwen Liu, Yuan Xu, Chunting Chen, Jie Yi, Fanglin Yu, Baosong Xie, Fei He

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of cancer survivorship : research and practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xi ChenDepartment of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, 350122, Fujian Province, China.
Jinman ZhuangDepartment of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, 350122, Fujian Province, China.
Zishan ChenDepartment of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, 350122, Fujian Province, China.
Shiwen LiuDepartment of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, 350122, Fujian Province, China.
Yuan XuClinical Research Center, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, 362000, Fujian Province, China.
Chunting ChenDepartment of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, 350122, Fujian Province, China.
Jie YiDepartment of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, 350122, Fujian Province, China.
Fanglin YuExperiment Center, School of Public Health, The Key Laboratory of Environment and Health, School of Public Health, Fujian Medical University, Fuzhou, China.
Baosong XieDepartment of Pulmonary and Critical Care Medicine, Fujian Provincial Hospital, Fujian Shengli Medical College, Fujian Medical University, Fuzhou, 350001, China. xbaosong@126.com.
Fei HeDepartment of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, 350122, Fujian Province, China. i.fei.he@fjmu.edu.cn.

Funding

Fujian Provincial Natural Science Foundation Project grant number 2023J01093
6 · The paper itself

Abstract

background and purposeAllostatic load (AL) significantly impacts patient outcomes. This study aimed to explore the association between AL levels and time to deterioration (TTD) of health-related quality of life (HRQoL) in non-small cell lung cancer (NSCLC) patients.

methodsA prospective study (May 2017-September 2022) included 362 NSCLC patients from The First Affiliated Hospital of Fujian Medical University. HRQoL was assessed using EORTC QLQ-C30 and EORTC QLQ-LC13 questionnaires, and AL-related biomarkers were collected. Univariate and multivariate Cox regression analyses evaluated the impact of AL on HRQoL TTD.

resultsTTD events were most common in global health status (QL), physical functioning (PF), and dyspnea (LC-DY). Lower AL levels delayed TTD in emotional functioning (EF) (HR = 2.041, 95% CI: 1.404-2.969, P < 0.001), cognitive functioning (CF) (HR = 1.613, 95% CI: 1.082-2.403, P = 0.019), insomnia (SL) (HR = 1.553, 95% CI: 1.064-2.266, P = 0.022), constipation (CO) (HR = 2.114, 95% CI: 1.179-3.791, P = 0.012), and hemoptysis (LC-HA) (HR = 2.316, 95% CI: 1.037-5.172, P = 0.041). Multivariate analysis confirmed these findings, except for insomnia, which lost significance.

conclusionsLower AL levels delayed TTD in EF, CF, CO, and LC-HA, highlighting AL's role in preserving HRQoL in NSCLC patients. IMPLICATIONS FOR CANCER SURVIVORS: HRQoL is critical for cancer survivors. This study underscores the importance of AL to improve HRQoL outcomes in NSCLC patients.

Indexed as

AllostasisCarcinoma, Non-Small-Cell LungLung NeoplasmsQuality of LifeAgedFemaleHealth StatusHumansMaleMiddle AgedProspective StudiesSurveys and QuestionnairesAllostatic LoadHealth-related quality of lifeNon-small cell lung cancerTime to Deterioration

Identifiers

PMID40736930

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.