Evidence map›Paper›PMID 40736876›Full record

ArticleInternational journal of geriatric psychiatry2025

Dose-Response Association of Handgrip Strength With Alzheimer's Disease: A Longitudinal Study Involving 85,979 Adults.

Rodrigo Núñez-Cortés, Joaquín Calatayud, Sergio Calonge-Pascual, Lars Louis Andersen, Rúni Bláfoss, José Francisco López-Gil, Rubén López-Bueno

Abstract read
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In one paragraph

Article in International journal of geriatric psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rodrigo Núñez-CortésDepartment of Physiotherapy, Physiotherapy in Motion Multispeciality Research Group (PTinMOTION), University of Valencia, Valencia, Spain.
Joaquín CalatayudNational Research Centre for the Working Environment, Copenhagen, Denmark.ORCID https://orcid.org/0000-0002-8670-8346
Sergio Calonge-PascualREDAFLED Research Group, Departamento de Didáctica de la Expresión Musical, Plástica y Corporal, Facultad de Educación, Universidad de Valladolid, Soria, Spain.ORCID https://orcid.org/0000-0003-3523-4539
Lars Louis AndersenNational Research Centre for the Working Environment, Copenhagen, Denmark.ORCID https://orcid.org/0000-0003-2777-8085
Rúni BláfossNational Research Centre for the Working Environment, Copenhagen, Denmark.ORCID https://orcid.org/0000-0003-1843-6884
José Francisco López-GilSchool of Medicine, Universidad Espíritu Santo, Samborondón, Ecuador.ORCID https://orcid.org/0000-0002-7412-7624
Rubén López-BuenoNational Research Centre for the Working Environment, Copenhagen, Denmark.ORCID https://orcid.org/0000-0002-7865-3429

Funding

DG Employment, Social Affairs and Inclusion. Additional funding from the German Ministry of Education and Research, the Max Planck Society for the Advancement of Science, the U.S. National Institute IAG_BSR06-11DG Employment, Social Affairs and Inclusion. Additional funding from the German Ministry of Education and Research, the Max Planck Society for the Advancement of Science, the U.S. National Institute OGHA_04-064DG Employment, Social Affairs and Inclusion. Additional funding from the German Ministry of Education and Research, the Max Planck Society for the Advancement of Science, the U.S. National Institute P01_AG005842DG Employment, Social Affairs and Inclusion. Additional funding from the German Ministry of Education and Research, the Max Planck Society for the Advancement of Science, the U.S. National Institute P01_AG08291DG Employment, Social Affairs and Inclusion. Additional funding from the German Ministry of Education and Research, the Max Planck Society for the Advancement of Science, the U.S. National Institute P30_AG12815DG Employment, Social Affairs and Inclusion. Additional funding from the German Ministry of Education and Research, the Max Planck Society for the Advancement of Science, the U.S. National Institute R21_AG025169DG Employment, Social Affairs and Inclusion. Additional funding from the German Ministry of Education and Research, the Max Planck Society for the Advancement of Science, the U.S. National Institute U01_AG09740-13S2DG Employment, Social Affairs and Inclusion. Additional funding from the German Ministry of Education and Research, the Max Planck Society for the Advancement of Science, the U.S. National Institute Y1-AG-4553-01Horizon 2020 SERISS: GA N°654221Horizon 2020 SHARE-COHESION: GA N°870628Horizon 2020 SHARE-DEV3: GA N°676536Horizon 2020 SSHOC: GA N°823782NIA NIH HHS HHSN271201300071CThe SHARE data collection has been funded by the European Commission COMPARE: CIT5-CT-2005-028857The SHARE data collection has been funded by the European Commission DASISH: GA N°283646The SHARE data collection has been funded by the European Commission QLK6-CT-2001-00360The SHARE data collection has been funded by the European Commission SHARE-I3: RII-CT-2006-062193The SHARE data collection has been funded by the European Commission SHARE-LEAP: GA N°227822The SHARE data collection has been funded by the European Commission SHARELIFE: CIT4-CT-2006-028812The SHARE data collection has been funded by the European Commission SHARE M4: GA N°261982The SHARE data collection has been funded by the European Commission SHARE-PREP: GA N°211909
6 · The paper itself

Abstract

objectiveTo investigate the dose-response relationship between handgrip strength and incidence of Alzheimer's disease (AD) in middle-aged and older adults.

designLongitudinal study. PATIENTS AND

methodsA longitudinal study was conducted in people over 50 years old in 27 European countries and Israel. Data were collected from waves 1, 2, 4, 5, 6, 7 and 8 of the Survey of Health, Ageing and Retirement in Europe (SHARE) between February 2004 and January 2021. Handgrip strength was measured with a hand dynamometer. AD was self-reported based on previous diagnosis. Dose-response associations were assessed by restricted cubic splines.

resultsA total of 85,979 (55.8% female) participants were followed for a median of 9.3 years. Over this time, 3324 (3.9%) developed AD. In the adjusted model, for participants < 65 years, those in the middle third of handgrip strength showed a lower risk of AD compared to the lower third (HR = 0.63, 95% CI: 0.47-0.84), as well as participants in the upper third (HR = 0.63, 95% CI: 0.47-0.85). The spline model determined that the minimum and optimal doses of handgrip strength for a significant reduction in the risk of AD for those aged < 65 years were 54 kg (HR = 0.99; 95% CI: 0.08-0.99) and 56 kg (HR = 0.27; 95% CI: 0.08-0.91), respectively. Among those aged ≥ 65 years, the minimum and optimal doses were 31 kg (HR = 0.69; 95% CI: 0.48-0.99) and 49 kg (HR = 0.57; 95% CI: 0.43-0.76), respectively.

conclusionHigher levels of handgrip strength showed a lower risk of developing AD, among adults aged 50 years and over. However, the dose-response relationship is limited to specific ranges according to age group. We identified a range between 54 and 56 kg years and a range between 31 and 49 kg as suitable to prevent AD in adults aged 50-64 and ≥ 65 years, respectively. Routine assessment of hand grip strength can help healthcare professionals identify people at increased risk of AD. Strength-based interventions could provide a practical strategy to support cognitive health and reduce the risk of dementia in clinical practice.

Indexed as

Alzheimer DiseaseHand StrengthAgedAged, 80 and overEuropeFemaleHumansIncidenceIsraelLongitudinal StudiesMaleMiddle AgedRisk Factorscut‐off pointsdementiaexercisemuscle strength dynamometer

Identifiers

PMID40736876
PMCPMC12309640

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