ReviewOphthalmology and therapy2025
Outcomes of Trabeculectomy and Glaucoma Drainage Device Surgery in Congenital Aniridia-Associated Glaucoma: A Systematic Review and Meta-Analysis.
Review in Ophthalmology and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Association of Topical Therapy and Surgical Management with Corneal Parameters in Congenital PAX6-Related Classical Aniridia: a Cross-Sectional Study.Ophthalmology and therapy · 2026Article
- Aniridia-associated keratopathy: Clinical and molecular mechanisms of disease progression and emerging therapeutic targets.Acta ophthalmologica · 2026Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThis study aimed to compare the surgical outcomes of trabeculectomy and glaucoma drainage device (GDD) implantation in patients with congenital aniridia.
methodsEligible studies were retrieved from Embase, MEDLINE (via PubMed), and the Cochrane Central Register of Controlled Trials (CENTRAL) up to December 15, 2024. Studies were included if they reported clinical outcomes following trabeculectomy or GDD implantation in individuals with aniridic glaucoma. Outcomes of interest included success rates, best spectacle-corrected visual acuity (BSCVA), intraocular pressure (IOP), use of glaucoma medications, and postoperative complications. Data extraction and synthesis were conducted according to the Cochrane Handbook. Meta-analyses were performed using a random-effects model. Heterogeneity among studies was evaluated using the Q test and I
resultsTwenty-two of the 1039 screened studies were included in the meta-analysis. Pooled complete success rates were not significantly different between trabeculectomy and GDD treatments (p = 0.88). However, the qualified success rate was significantly higher following GDDs compared to trabeculectomy (p < 0.001) in patients with aniridia. Cox frailty regression analysis of individual success data showed similar results: the hazard ratio of failure was significantly higher after trabeculectomy than after GDD (HR 5.684 from 1.46 to 22.14, p = 0.012). No significant differences were observed between the two procedures in terms of IOP reduction (p = 0.53), percentage change in IOP (p = 0.24), or reduction in glaucoma medications (p = 0.56) at final follow-up. Additionally, there was no significant difference in the change in BSCVA between the two groups (p = 0.72).
conclusionRegarding complete success rates, trabeculectomy does not seem to provide a significant benefit over GDDs in treating aniridic glaucoma. However, the qualified success rate is greater with GDD implantation than with trabeculectomy. Both surgical approaches show similar effectiveness in lowering intraocular pressure, reducing the need for glaucoma medications, and maintaining visual acuity.
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