Evidence map›Paper›PMID 40736774›Full record

ArticleAllergy, asthma & immunology research2025

Prevalence and Clinical Characteristics of Severe Asthma With Fungal Sensitization in Korea.

Hyo-In Rhyou, Tae-Bum Kim, Sun-Young Yoon, Jae-Woo Kwon, Hye-Kyung Park, Sung-Ryeol Kim, Young-Hee Nam, Joo-Hee Kim, Young-Joo Cho, Ho Joo Yoon and 16 more

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In one paragraph

Article in Allergy, asthma & immunology research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Hyo-In RhyouDepartment of Internal Medicine, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.ORCID https://orcid.org/0000-0003-0905-4649
Tae-Bum KimDepartment of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0001-5663-0640
Sun-Young YoonDepartments of Allergy and Pulmonology in Internal Medicine, Chungnam National University, Chungnam National University Sejong Hospital, Sejong, Korea.ORCID https://orcid.org/0000-0002-4205-1434
Jae-Woo KwonDepartment of Internal Medicine, Kangwon National University School of Medicine, Chuncheon, Korea.ORCID https://orcid.org/0000-0003-1639-3606
Hye-Kyung ParkDepartment of Internal Medicine, Pusan National University School of Medicine, Busan, Korea.ORCID https://orcid.org/0000-0003-4065-2962
Sung-Ryeol KimDivision of Pulmonology, Allergy and Critical Care Medicine, Department of Internal Medicine, Yongin Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0001-7418-0049
Young-Hee NamDepartment of Internal Medicine, Dong-A University School of Medicine, Busan, Korea.ORCID https://orcid.org/0000-0001-8759-2982
Joo-Hee KimDepartment of Internal Medicine, Hallym University College of Medicine, Anyang, Korea.ORCID https://orcid.org/0000-0002-1572-5149
Young-Joo ChoDepartment of Internal Medicine, Ewha Womans University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-9414-5934
Ho Joo YoonDepartment of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-4645-4863
Yoo Seob ShinDepartment of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea.ORCID https://orcid.org/0000-0002-9855-3185
Jae-Woo JungDepartment of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-3411-735X
Taehoon LeeDepartment of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.ORCID https://orcid.org/0000-0002-9224-0866
Yoon-Seok ChangDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.ORCID https://orcid.org/0000-0003-3157-0447
Sang-Heon ChoDepartment of Internal Medicine, Seoul National University Hospital, Seoul, Korea.ORCID https://orcid.org/0000-0002-7644-6469
Seung-Eun LeeDepartment of Internal Medicine, Pusan National University Yangsan Hospital, Yangsan, Korea.ORCID https://orcid.org/0000-0002-4266-7722
Byung-Jae LeeDivision of Allergy, Department of Medicine, Samsung Medical Center, Sungkyunkwan University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0001-6940-0836
Hwa Young LeeDivision of Allergy, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.ORCID https://orcid.org/0000-0002-1582-2256
Hyun Jung JinDepartment of Internal Medicine, Yeungnam University College of Medicine, Daegu, Korea.ORCID https://orcid.org/0000-0003-2888-420X
So-Young ParkDepartment of Internal Medicine, Chung-Ang University College of Medicine, Gwangmyeong, Korea.ORCID https://orcid.org/0000-0002-5224-3077
Kyoung-Hee SohnDivision of pulmonology and Allergy, Department of Internal Medicine, Kyung Hee University School of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0001-8407-8080
Byung Keun KimDivision of Pulmonology, Allergy and Critical Care Medicine, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0001-5147-6306
Youngsoo LeeDepartment of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea.ORCID https://orcid.org/0000-0001-8918-9353
Woo-Jung SongDepartment of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-4630-9922
Sang-Heon KimDepartment of Internal Medicine, Hanyang University Hospital, Hanyang University College of Medicine, Seoul, Korea. sangheonkim@hanyang.ac.kr.ORCID https://orcid.org/0000-0001-8398-4444
Chan Sun ParkDepartment of Internal Medicine, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea. mdpcs00@hanmail.net.ORCID https://orcid.org/0000-0003-0113-8354

Funding

Korea Health Industry Development Institute HC20C0076Korea Health Industry Development Institute HI19C0481Korea National Institute of Health 2025-ER1206-00
6 · The paper itself

Abstract

purposeSevere asthma with fungal sensitization (SAFS) is associated with life-threatening exacerbation and severe airflow limitation. We aimed to investigate the prevalence of fungal sensitization in asthma and clinical characteristics of SAFS.

methodsThis study analyzed data from the Cohort for Reality and Evolution of Adult Asthma in Korea and the Korean Severe Asthma Registry cohorts. Study subjects were classified based on fungal sensitization and asthma severity. Clinical characteristics of patients with severe asthma were compared according to fungal sensitization status.

resultsThe rate of skin test positivity to fungi was 14.1% and 7.1% in severe asthma (n = 270) and non-severe asthma (n = 2,605). Patients with SAFS were diagnosed with asthma earlier than those with severe asthma without fungal sensitization (SANFS) (

conclusionsThe prevalence of fungal sensitization in severe asthma is approximately twice as high as in non-severe asthma. Early diagnosed asthma may be a risk factor for SAFS, and patients with SAFS face a greater burden of additional treatment compared to those with SANFS. SAFS has a distinct airway inflammation profile that differentiates it from SANFS.

Indexed as

Asthmabiologicseosinophilsfungiimmunologic sensitizationneutrophils

Identifiers

PMID40736774
PMCPMC12318808

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.