ArticleJournal of neurology2025
RLS shows increased resting state sympathetic activity and decreased sympathetic response capability.
Article in Journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neuromodulation for Restless Legs Syndrome: A Systematic Review and Mechanistic Considerations for Spinal Cord Stimulation.Sleep & breathing = Schlaf & Atmung · 2026Pooled it
- Restless Legs Syndrome: A Network Model of Iron-Dependent Neuromodulation-A Narrative Review.Brain sciences · 2026Review
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundRestless Legs Syndrome (RLS) is a sensorimotor disorder characterized by painful discomfort, an urge to move the legs and circadian and sleep-wake disturbances. The pathophysiology is complex and not fully understood, with inhibitory dysfunction of dopaminergic neurons or increased sympathetic activity being discussed. Aim of this study was to shed light on the association between dysfunction of the autonomic nervous system and RLS.
methods6 RLS patients diagnosed according to consensus criteria were compared with 9 gender- and age-matched healthy controls. Patients were clinically characterized using the International RLS Severity Scale (IRLS), the Epworth Sleepiness Scale (ESS) and the RLS Quality of Life Questionnaire (RLSQoL). Multi-unit sympathetic microneurography was performed in the peroneal nerve. Cardiovascular parameters (systolic and diastolic blood pressure, heart rate) and muscle sympathetic nerve activity (MSNA) were assessed at rest and during baroreflex stimulation using lower body negative pressure (LBNP).
resultsMSNA at rest was higher in RLS patients (burst frequency [BF]: 42.4 ± 1.7 bursts/min; burst incidence [BI]: 64.0 ± 2.7 bursts/100 heartbeats) compared to controls (BF: 29.5 ± 1.4 bursts/min, F = 15.332, p = 0.002; BI: 42.9 ± 3.2 bursts/100 heartbeats, F = 21.156, p = 0.001). After baroreflex stimulation, RLS patients had increased absolute values of MSNA (BF: F = 15.096; p = 0.002; BI: F = 21.115; p < 0.001) compared to controls. In RLS patients, BF and BI dropped below baseline values, while in healthy controls BF and BI remained above baseline. After normalization of BF and BI data, the MSNA outflow during baroreflex stimulation was lower in RLS patients than those of healthy controls (BF: F = 4.574; p = 0.002, BI: F = 6.259; p < 0.001).
conclusionThe current study is the first to directly demonstrate increased sympathetic neuronal activity in RLS. Possible explanations include a dysfunction in inhibitory projections to sympathetic neurons in the intermediate lateral column of the spinal cord or a disease-unspecific effect of sleep deprivation.
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