Evidence map›Paper›PMID 40736693›Full record

ArticleThe American journal of gastroenterology2025

Measuring the Risk of Gluten Exposure: Development of the Gluten Exposure Risk Assessment in Pediatric Patients.

Amy E Hale, Monique Germone, Lisa Fahey, Marisa Stahl, Maureen M Leonard, Arunjot Singh, Temara Hajjat, Daniel Mallon, Benny Kerzner, Catherine Raber and 17 more

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In one paragraph

Article in The American journal of gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Amy E HaleDivision of Gastroenterology and Nutrition, Boston Children's Hospital, Boston, Massachusetts, USA.ORCID 0000-0002-9346-7261
Monique GermoneColorado Center for Celiac Disease, Digestive Health Institute, Children's Hospital Colorado, Aurora, Colorado, USA.ORCID 0000-0001-6827-5551
Lisa FaheyDivision of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Marisa StahlColorado Center for Celiac Disease, Digestive Health Institute, Children's Hospital Colorado, Aurora, Colorado, USA.ORCID 0000-0002-9656-5561
Maureen M LeonardCenter for Celiac Research and Treatment, Division of Gastroenterology, Hepatology and Nutrition, Mass General Hospital for Children, Boston, Massachusetts, USA.ORCID 0000-0002-5955-5102
Arunjot SinghDivision of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Temara HajjatDivision of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Cincinnati Children's Hospital and Medical Center, Cincinnati, Ohio, USA.
Daniel MallonDivision of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Cincinnati Children's Hospital and Medical Center, Cincinnati, Ohio, USA.ORCID 0000-0002-4126-9191
Benny KerznerDivision of Gastroenterology, Hepatology and Nutrition, Children's National Hospital, Washington, District of Columbia, USA.
Catherine RaberDivision of Gastroenterology, Hepatology and Nutrition, Children's National Hospital, Washington, District of Columbia, USA.ORCID 0000-0003-2832-8860
Vahe BadalyanDivision of Gastroenterology, Hepatology and Nutrition, Children's National Hospital, Washington, District of Columbia, USA.ORCID 0000-0002-1361-2079
Pooja MehtaColorado Center for Celiac Disease, Digestive Health Institute, Children's Hospital Colorado, Aurora, Colorado, USA.
Edwin LiuColorado Center for Celiac Disease, Digestive Health Institute, Children's Hospital Colorado, Aurora, Colorado, USA.ORCID 0000-0003-3591-8922
Mary ShullColorado Center for Celiac Disease, Digestive Health Institute, Children's Hospital Colorado, Aurora, Colorado, USA.
Imad AbsahDivision of Pediatric Gastroenterology, Hepatology and Nutrition, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0002-7565-870
Dale LeeDivision of Pediatric Gastroenterology and Hepatology, Seattle Children's Hospital, Seattle, Washington, USA.
Tracy EdigerDivision of Gastroenterology, Hepatology and Nutrition, Nationwide Children's Hospital, Columbus, Ohio, USA.ORCID 0000-0002-7080-486
Ritu VermaSection of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, The University of Chicago, Chicago, Illinois, USA.ORCID 0009-0007-0289-3489
Hilary JerichoStanford University, Palo Alto, California, USA.ORCID 0009-0007-9248-1911
Nasim KhavariDivision of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Celiac Disease Center, Stanford University, Lucile Packard Children's Hospital, Palo Alto, California, USA.
Jackie JossenDepartment of Pediatrics, Morgan Stanley Children's Hospital, Columbia University, New York, New York, USA.ORCID 0009-0005-0279-673
Randi L WolfDepartment of Health Studies and Applied Educational Psychology, Program in Nutrition, Teachers College, Columbia University, New York, New York, USA.ORCID 0000-0002-8155-3082
Madison WongHarvard Celiac Disease Research Program, Boston Children's Hospital, Boston, Massachusetts, USA.ORCID 0009-0003-9504-4590
Stephanie RegisHarvard Celiac Disease Research Program, Boston Children's Hospital, Boston, Massachusetts, USA.ORCID 0000-0002-6756-9715
Vanessa WeisbrodCeliac Disease Foundation, Woodland Hills, California, USA.ORCID 0000-0001-6124-4445
Jocelyn A SilvesterDivision of Gastroenterology and Nutrition, Boston Children's Hospital, Boston, Massachusetts, USA.ORCID 0000-0002-3615-1666
RAISE-CD

Funding

Prospective Multi-Omic Analysis of At-Risk infants to Model Celiac Disease PathogenesisK23DK122127 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI LEONARD, MAUREEN MICHELLE · 2019 to 2023
$1.2M
Mechanisms and Markers of Small Intestinal Epithelial Injury and Villous AtrophyK23DK119584 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI SILVESTER, JOCELYN ANNE · 2019 to 2023
$971k
NIDDK NIH HHS K23 DK119584NIDDK NIH HHS K23DK119584NIDDK NIH HHS K23 DK122127NIDDK NIH HHS K23DK122127
6 · The paper itself

Abstract

introductionTreatment of celiac disease (CeD) requires a strict gluten-free diet (GFD). Adherence is difficult to assess and influenced by many factors. Identification of potential gluten exposures is essential, but no validated screening measures exist in pediatrics. The aim of this study was to develop and validate a measure screening for gluten exposure risk in pediatric patients with CeD.

methodsThe Gluten Exposure Risk Assessment (GERA) was developed in 3 phases. First, items were generated and refined by a modified Delphi process. Next, psychometrics, factor structure, and validity were examined in a sample of caregivers of pediatric patients younger than 18 years with CeD at 12 pediatric celiac centers. Finally, the final measure was tested on an independent sample population using confirmatory factor analysis and test-retest data.

resultsA total of 134 items were generated representing up to 6 domains, with 36 items selected for initial testing. Based on psychometrics and confirmatory factor analysis data from 484 caregivers, the final measure included a total of a single screening question and 9 validated items representing 2 domains (Home, Outside). Repeat testing on a separate sample (N = 369) confirmed factor structure and validity of the final measure (Comparative Fit Index = 0.96, Tucker-Lewis index = 0.95, root mean square error of approximation = 0.06). DISCUSSION: The GERA is a valid screening measure, completed by caregivers, for assessment of gluten exposure in children and adolescents with CeD following a GFD. GERA is a useful tool for evaluating the potential of risk of gluten exposure and potential need for intervention.

Indexed as

adherenceceliac diseasegluten exposure riskgluten-free diettreatment

Identifiers

PMID40736693
PMCPMC13177727

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