Evidence map›Paper›PMID 40736657›Full record

ArticleInternational microbiology : the official journal of the Spanish Society for Microbiology2025

Exploration of anti-quorum sensing properties of eicosyl heptafluorobutyrate against a clinical strain of Pseudomonas aeruginosa.

Siddhi D Shah, Saklain Mustak Saiyad, Mirav Patel, Gyan Prakash Rai, Asheesh Shanker, Bhakti Bajpai

Abstract read
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In one paragraph

Article in International microbiology : the official journal of the Spanish Society for Microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Siddhi D ShahAshok & Rita Patel Institute of Integrated Study and Research in Biotechnology and Allied Sciences (ARIBAS), The CVM University, Vallabh Vidyanagar, Anand, 388120, Gujarat, India.ORCID http://orcid.org/0000-0003-0532-6897
Saklain Mustak SaiyadAshok & Rita Patel Institute of Integrated Study and Research in Biotechnology and Allied Sciences (ARIBAS), The CVM University, Vallabh Vidyanagar, Anand, 388120, Gujarat, India.ORCID http://orcid.org/0009-0000-2192-3179
Mirav PatelDepartment of Biotechnology, Parul Institute of Applied Sciences, Research and Development Centre, Parul University, Vadodara, 391760, Gujarat, India.ORCID http://orcid.org/0000-0003-0479-8390
Gyan Prakash RaiDepartment of Bioinformatics, Central University of South Bihar, Gaya, Bihar, 824236, India.ORCID http://orcid.org/0000-0003-4165-293X
Asheesh ShankerDepartment of Bioinformatics, Central University of South Bihar, Gaya, Bihar, 824236, India.
Bhakti BajpaiBhaikaka University, Karamsad, Anand, 388325, Gujarat, India. bhaktibajpai0405@gmail.com.ORCID http://orcid.org/0000-0001-5288-1725

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pseudomonas aeruginosa is a multidrug-resistant (MDR) pathogen. It causes life-threatening diseases through quorum sensing (QS)-associated virulence. Thus, the attenuation of QS may be an effective strategy to combat the pathogen. In this study, Shewanella indica SU1 isolated from the marine environment showed QS inhibitory activity against biosensor strain Chromobacterium violaceum MTCC 2656. The lead compound was purified and tentatively identified as eicosyl heptafluorobutyrate (EPB). P. aeruginosa MCC 3457 was treated with EPB, and results revealed a reduced production of pyocyanin (79%), rhamnolipids (54%), exopolysaccharide (60%), and biofilm (66%). The motility was greatly affected in EPB-treated cultures. In an in silico approach, EPB exhibited good binding interactions and stability with the target protein LasR. The pharmacokinetics studies divulged that EPB, the lead compound, can be a good drug candidate. This is the first report on the QS inhibitory activity of S. indica SU1 and EPB as an anti-QS compound.

Indexed as

Anti-Bacterial AgentsPseudomonas aeruginosaQuorum SensingBacterial ProteinsBiofilmsChromobacteriumGlycolipidsMicrobial Sensitivity TestsPseudomonas InfectionsPyocyanineTrans-ActivatorsAnti-Bacterial AgentsBacterial ProteinsGlycolipidsLasR protein, Pseudomonas aeruginosaPyocyaninerhamnolipidTrans-ActivatorsAnti-quorum sensingEicosyl heptafluorobutyrateEpibiotic bacteriaPseudomonas aeruginosaQuorum sensingShewanella indica

Identifiers

PMID40736657

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.