ArticleVeterinary medicine and science2025
Relationship between Urine Protein-To-Creatinine Ratio and Leukocyte Esterase in Canine Urine Samples.
Article in Veterinary medicine and science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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3 authors.
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Abstract
backgroundThe urine dipstick strip test is used for detecting urinary leukocytes and protein; however, factors like specific gravity, pH and infection may affect accuracy. Concerns exist regarding white blood cells interfering with the urine protein-to-creatinine (UP/C) ratio, a key test for proteinuria.
objectivesThis study aimed to determine whether the results of the leukocyte esterase test affect the UP/C ratio in canine urine samples.
methodsA total of 186 canine urine samples were collected. The dipstick strip leukocyte esterase test was used to classify the specimens into two groups: leukocyte strip-positive (+) and leukocyte strip-negative (-). The UP/C ratio was then measured for all samples employing the Catalyst One biochemical analyser.
resultsThe absolute value of the correlation coefficient between leukocyte strip status (±) and the UP/C ratio was 0.014 (p = 0.849), indicating no significant correlation. When applying the International Renal Interest Society (IRIS) grading criteria and setting the threshold for abnormal UP/C at ≥ 0.2, no significant correlation was found between leukocyte strip status and abnormal UP/C (p = 0.490). When categorising the UP/C ratio according to IRIS classification criteria, the absolute value of the correlation coefficient between leukocyte strip status and UP/C classification was 0.032 (p = 0.661), again showing no association. These findings suggest that a positive leukocyte esterase test does not interfere with the UP/C ratio.
conclusionsThe presence of a positive leukocyte esterase test does not affect the UP/C ratio in canine urine samples. Therefore, the UP/C ratio test can be performed regardless of the results of the leukocyte esterase test.
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