ArticleEuropean journal of nuclear medicine and molecular imaging2026
Vasculature cast sign on
Article in European journal of nuclear medicine and molecular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
purposeTo evaluate the diagnostic performance of
methodsPretreatment
resultsThe vasculature cast sign was present in 15/24 T-LBL cases, with high specificity (97.2%) and positive predictive value (93.8%) but moderate sensitivity (62.5%). Intra- and interobserver agreement were 0.91 and 0.83, respectively. T-LBL had significantly larger tumor dimension (Dmax), lower SUVmax of the tumor or the spleen, higher total or mediastinal tumor metabolic tumor volume with a threshold of 41% of SUVmax and more frequent aortic arch encasement compared to nonT-LBL. Multivariable logistic regression identified the vasculature cast sign (odds ratio [OR], 37.45, 95% CI: 1.83-767.64, p = 0.019), tumor SUVmax (OR, 0.82, 95% CI: 0.69-0.97, p = 0.023) and Dmax > 6.85 cm (OR, 16.67; 95% CI: 1.76-158.21, p = 0.014) as independent imaging markers for T-LBL. Model combining these parameters yielded an area under the curve of 0.943 (p < 0.001), and a simplified scoring system was developed based on the three parameters, yielding the diagnostic rates of 0% (0/8), 14.3% (3/21), 40% (6/15), and 100% (15/15) for scores of 0, 1, 2, and 3, respectively.
conclusionThe vasculature cast sign is a specific and reproducible PET/CT marker of T-LBL.
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