ArticleEuropean journal of nuclear medicine and molecular imaging2025
Translocator protein (TSPO) positron emission tomography imaging and expression in patients with brain metastases.
Article in European journal of nuclear medicine and molecular imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purpose18 kDa translocator protein (TSPO) is a biomarker for inflammatory conditions. However, full kinetic positron emission tomography (PET) modeling has rarely been used to quantify brain tumors, and it has never been used in brain metastases (BMs). This proof-of-principle study quantified TSPO expression using full kinetic modeling in patients with BMs from various types of peripheral primary tumors.
methodsNine adult patients with BMs and 12 healthy volunteers (HVs) took part in the study. The total distribution volume (V
results
conclusionIn this pilot study, full kinetic modeling quantified TSPO expression in BMs with good fit and precision. The kinetic modeling outcome parameters and the TSPO expression levels in vitro suggest that
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