Evidence map›Paper›PMID 40736553›Full record

Trial reportWiener klinische Wochenschrift2026

Prospective, randomized study on the effects of autologous concentrated growth factors in the treatment of cystic lesions of the jaw.

Christoph Sacher, Daniel Holzinger, Florian Wagner, Moritz Bechtold, Robert Pillerstorf, Simon Bigus

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Wiener klinische Wochenschrift, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Christoph SacherDepartment of Oral and Maxillofacial Surgery, University Hospital Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria. Ordination@dr-sacher.at.ORCID http://orcid.org/0000-0002-6888-8232
Daniel HolzingerDepartment of Oral and Maxillofacial Surgery, University Hospital Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.
Florian WagnerDepartment of Oral and Maxillofacial Surgery, University Hospital Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.
Moritz BechtoldDepartment of Oral and Maxillofacial Surgery, University Hospital Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.
Robert PillerstorfDepartment of Oral and Maxillofacial Surgery, University Hospital Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.
Simon BigusDepartment of Oral and Maxillofacial Surgery, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe aim of the study was to investigate the efficacy of autologous concentrated growth factors (aCGF) in the treatment and healing of cystic lesions of the jaw. MATERIAL AND

methodsIn this prospective randomized intervention study 138 patients were enrolled, with 68 patients undergoing cystectomy alone and 70 patients undergoing cystectomy with defect filling using autologous concentrated growth factors. Bone healing was volumetrically measured using cone beam computed tomography (CBCT) at 6 and 12 months postoperatively. Clinical follow-ups were conducted 14 days, 1 month, 3 months, 6 months, and 12 months after the treatment.

resultsIn both groups, almost complete bone healing occurred, with no significant differences observed between the two groups (P =0.484). In the aCGF group there was a trend towards a reduction in wound healing disturbances after 14 days, although this reduction was not statistically significant (P =0.071).

conclusionThe use of aCGF following cystectomy does not show radiologically measurable significantly improved bone healing; however, a tendency towards improved wound healing compared to cystectomy without any filling materials could be observed in the initial healing period.

Indexed as

Intercellular Signaling Peptides and ProteinsJaw CystsAdultAgedCone-Beam Computed TomographyFemaleHumansMaleMiddle AgedProspective StudiesTreatment OutcomeWound HealingIntercellular Signaling Peptides and ProteinsBone healingCystectomyCystic lesionOral surgeryWound healing

Identifiers

PMID40736553
PMCPMC12830443

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.