SynthesisAnnals of hematology2025
Prognostic significance of in patients with chronic lymphocytic leukemia: A meta-analysis.
Synthesis in Annals of hematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Prognostic and predictive impact of NOTCH1 mutations in patients with chronic lymphocytic leukemia: a tertiary single-center experience.Frontiers in oncology · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
NOTCH1 and SF3B1 mutations are common in CLL, but their prognostic value for overall survival (OS) and progression-free survival (PFS), as well as time to first treatment (TTFT) and treatment-free survival (TFS), remains uncertain. This meta-analysis systematically evaluates their impact. A systematic search of PubMed, Embase, Cochrane Library, and Web of Science was performed up to March 2025. Relevant study data and prognostic outcomes were extracted, and pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated using fixed- or random-effects models based on heterogeneity. A total of 38 studies with 24,060 CLL patients met the criteria. Among them, 32 and 23 studies evaluated the prognostic impact of NOTCH1 and SF3B1 mutations, respectively. Compared to wild-type, NOTCH1 mutations were associated with worse OS (HR = 1.88), PFS (HR = 1.42), TTFT (HR = 1.63), and TFS (HR = 2.46). SF3B1 mutations similarly predicted poor OS (HR = 1.68), with HRs of 1.63, 1.24, and 1.70 for PFS, TTFT, and TFS. Subgroup analysis showed worse OS in older and treatment-naïve patients. These findings suggest that NOTCH1 and SF3B1 mutations are significant adverse prognostic markers in CLL. Increasing evidence supports their inclusion in clinical risk stratification and personalized treatment planning, especially when combined with patient-specific clinical and molecular features.
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Registered trials
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