ArticleKorean journal of radiology2025
Association of Hypoxic-Ischemic Injury of the Brain With MRI-Derived Glymphatic Function Parameters in Neonates.
Article in Korean journal of radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Imaging Biomarkers of the Glymphatic System in the Developing Brain.Korean journal of radiology · 2026Review
- Disrupted age-related glymphatic patterns in children with deep gray matter hypoxic-ischemic encephalopathy: a diffusion tensor imaging analysis along the perivascular space study.Neuroradiology · 2026Article
- Pilot study of association between neonatal brain perivascular space volume and neurodevelopmental outcomes at 24 months.BMC medical imaging · 2025Article
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Authors and funding
6 authors.
Funding
Abstract
objectiveTo evaluate the association between hypoxic-ischemic injury (HII) of the brain and glymphatic function using MRI-derived parameters in neonates. MATERIALS AND
methodsThis retrospective, single-institution study collected brain MRI scans of 127 neonates between July 2020 and July 2022. The volume and fraction of the basal ganglia perivascular space (BG-PVS) were automatically extracted using three-dimensional T2-weighted image processing. Diffusion-tensor imaging (DTI) along the PVS (DTI-ALPS) index values were derived from the DTI maps. BG-PVS and DTI-ALPS parameters were compared between neonates with and without HII. The correlations between MRI-derived glymphatic parameters and corrected gestational age (CGA), as well as between BG-PVS measurements and the DTI-ALPS index, were analyzed using Spearman coefficients. Multivariable logistic regression adjusted for age, sex, birth weight, and mode of delivery was performed to examine the associations between each glymphatic parameter and HII.
resultsThis study included 97 neonates without HII (median gestational age [GA]: 252 days) and 30 with HII (median GA: 252 days). Neonates with HII had smaller BG-PVS volumes (19 mm³ vs. 33 mm³,
conclusionNeonates with HII demonstrated smaller BG-PVS volume and fraction compared with those without HII, indicating potential alterations in glymphatic function among affected newborns.
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