Association Between Lymphocyte-High Density Lipoprotein Ratio and Cognitive Impairment in Chinese Older Adults: A Population-Based Cross-Section Study.

Jinhui Yang, Wenbin Lu, Hao Wang, Xiaofei Li, Liangliang Lu, Jinjun Bian, Xiaoming Deng

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Article in American journal of Alzheimer's disease and other dementias. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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7 authors.

Jinhui YangDepartment of Anesthesiology, Changhai Hospital, Naval Military Medical University, Shanghai, China.ORCID 0009-0002-4120-7393

Wenbin LuDepartment of Anesthesiology, Changhai Hospital, Naval Military Medical University, Shanghai, China.ORCID 0000-0002-0000-2546

Hao WangDepartment of Anesthesiology, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, China.

Xiaofei LiDepartment of Anesthesiology, Changhai Hospital, Naval Military Medical University, Shanghai, China.

Liangliang LuDepartment of Anesthesiology, Changhai Hospital, Naval Military Medical University, Shanghai, China.

Jinjun BianDepartment of Anesthesiology, Changhai Hospital, Naval Military Medical University, Shanghai, China.ORCID 0000-0001-6225-7272

Xiaoming DengDepartment of Anesthesiology, Changhai Hospital, Naval Military Medical University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

ObjectiveTo explore the association between lymphocyte-high density lipoprotein ratio (LHR) and cognitive impairment in Chinese older adults.MethodsThis study included participants aged ≥65 years from the 2008 to 2014 waves of the Chinese Longitudinal Healthy Longevity Survey (CLHLS). Cognitive function was assessed using the Mini-Mental State Examination, with a score of less than 24 points considered indicative of cognitive impairment. Multiple logistic regression analysis and restricted cubic spline were applied to investigate the association between LHR and cognitive impairment.ResultsOf 3556 participants, 1625 (45.7%) suffered from cognitive impairment. Multivariate logistic regression analysis indicated that low LHR was associated with cognitive impairment [odds ratio (OR) = 1.34; 95% confidence interval (CI) = 1.11-1.62, P = 0.002].ConclusionsLower LHR was associated with cognitive impairment in Chinese older people. This finding suggests LHR could serve as a novel and accessible biomarker for identifying high-risk aging populations.

Indexed as

Cognitive DysfunctionLipoproteins, HDLLymphocytesAgedAged, 80 and overBiomarkersChinaCross-Sectional StudiesEast Asian PeopleFemaleHumansLongitudinal StudiesMaleBiomarkersLipoproteins, HDLChinese older adultscognitive impairmentcross-section studylinear relationlymphocyte-high density lipoprotein ratio

Identifiers

PMID40736399

DOI10.1177/15333175251361748

PMCPMC12317171

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.