ArticleKorean circulation journal2025
Impact of the New Definition on the Prognosis of Patients With Pulmonary Hypertension Compared to the Classic Definition.
Article in Korean circulation journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07707193 (Assessment of Right Ventricular-Pulmonary Arterial Coupling in Schistosomiasis-Associated Pulmonary Arterial Hypertension), which is not on this map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Assessment of Right Ventricular-Pulmonary Arterial Coupling in Schistosomiasis-Associated Pulmonary Arterial Hypertension
Who cites it
2 citing papers in PubMed.
- Mid-term prognosis and risk stratification in patients with post-operative pulmonary hypertension: Insights from the Japanese Association of Congenital Heart Disease Registry (JACPHR).American heart journal plus : cardiology research and practice · 2026Article
- Pulmonary Hypertension Redefined: From Historical Thresholds to Prognostic Relevance.Korean circulation journal · 2025Article
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Authors and funding
8 authors.
Funding
Abstract
BACKGROUND AND
objectivesThe 2022 European Society of Cardiology (ESC)/European Respiratory Society (ERS) guidelines updated the definition of pulmonary hypertension (PH). This study aimed to evaluate implications of the new PH definition.
methodsA retrospective analysis of a single-center right heart catheterization registry (April 2016-July 2023) was conducted. Patients were classified using the classic definition (mean pulmonary arterial pressure [mPAP] ≥25 mmHg, pulmonary vascular resistance [PVR] >3 Wood units [WU]) and the new definition (mPAP >20 mmHg, PVR >2 WU). The primary outcome was a composite of cardiovascular death or heart failure (HF) hospitalization over a maximum follow-up of 5 years.
resultsAmong 314 patients (median age, 62.5 years; male, 50.3%), the new definition led to a 9.6% increase in diagnosis of pre-capillary PH (Pre-PH) and a 10.5% increase in combined pre- and post-capillary PH (Cpc-PH). Event discrimination was comparable between the 2 definitions, as assessed by the C-index and net reclassification improvement. Multivariable Cox regression, adjusted for age and sex, showed a lower risk of cardiovascular death or HF hospitalization under the new definition. Spline analyses indicated that risk increased from mPAP >20 mmHg and PVR >2 WU.
conclusionsThe new definition increased PH diagnoses, particularly in Pre-PH and Cpc-PH, while maintaining comparable discriminative performance. Improved 5-year event-free survival observed under the new definition may be partly attributable to the inclusion of patients with milder disease. Notably, the risk progressively increased beyond mPAP >20 mmHg and PVR >2 WU, reinforcing the prognostic significance of the new thresholds.
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