Evidence map›Paper›PMID 40736366›Full record

ArticleCritical care medicine2025

Epidemiology of Substance-Related Admissions to ICUs in the United States.

Kelsey Hills-Dunlap, Max McGrath, Ryan Peterson, P Michael Ho, Tyree H Kiser, R William Vandivier, Ellen L Burnham, Marc Moss, Sarah E Jolley

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Critical care medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kelsey Hills-DunlapDivision of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO.ORCID 0000-0003-0288-4914
Max McGrathDepartment of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO.
Ryan PetersonDepartment of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO.
P Michael HoDivision of Cardiology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO.
Tyree H KiserColorado Pulmonary Outcomes Research Group (CPOR), Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO.
R William VandivierDivision of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO.
Ellen L BurnhamDivision of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO.
Marc MossDivision of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO.
Sarah E JolleyDivision of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO.

Funding

Development of a Novel Peer-Narrated Virtual Patient Decision Aid for Entry into Alcohol Treatment for ICU Survivors with Alcohol MisuseF32AA030915 · NIAAA · UNIVERSITY OF COLORADO DENVER · PI HILLS-DUNLAP, KELSEY R · 2023 to 2024
$172k
NIAAA NIH HHS F32 AA030915
6 · The paper itself

Abstract

objectivesTo determine the prevalence, demographic characteristics, and predictors of in-hospital mortality for substance-related ICU admissions in the United States.

designMulticenter, retrospective cohort study.

settingU.S. ICUs reporting data to the nationally representative Premier Healthcare Database between 2016 and 2019. PATIENTS: Adult ICU admissions with an International Classification of Diseases , 10th Revision diagnosis of a substance-related disorder not in remission.

interventionsNone. MEASUREMENTS AND MAIN

resultsAmong 4,740,799 ICU admissions, a substance-related diagnosis was present in 760,153 (mean age 51.8 yr, 65.5% male, 73.7% White, 74.5% non-Hispanic), representing 16.0% (95% CI, 16.00-16.07%) of all ICU admissions or approximately one of every six ICU admissions. Alcohol was the most common substance associated with ICU admission (8.9% of all encounters; 95% CI, 8.87-8.92%), followed by opioids and stimulants (4.0%; 95% CI, 3.97-4.01% and 2.9%; 95% CI, 2.91-2.94%, respectively). Rates of nearly all substance-related ICU admissions were higher in patients 55-64 years old and in patients who identified as male, non-Hispanic, and "Other" race (not identified as White, Black, or Asian). In comparing White and Black patients, the two largest racial groups within our cohort, opioid-related ICU admission rates were higher in White patients while stimulant-related ICU admission rates were higher in Black patients. Only 6.5% (95% CI, 6.37-6.60%) of opioid-related ICU admissions identified heroin use. In multivariable analysis adjusting for relevant covariates, odds of in-hospital mortality following a substance-related ICU admission were higher for encounters that included alcohol-related diagnoses (adjusted odds ratio [aOR], 1.12; 95% CI, 1.06-1.19), female sex (aOR, 1.07; 95% CI, 1.04-1.09), and non-Hispanic ethnicity (aOR, 1.08; 95% CI, 1.01-1.16).

conclusionsA substantial burden of substance-related diagnoses exists in patients admitted to ICUs. Alcohol use was most common and associated with increased hospital mortality relative to other substances. Rates of substance-related ICU admission differed by age, sex, race, and ethnicity. These findings may have implications for effective allocation of resources toward addiction-related diagnoses, treatment, and secondary prevention for ICU patients.

Indexed as

Intensive Care UnitsPatient AdmissionSubstance-Related DisordersAdultAgedFemaleHospital MortalityHumansMaleMiddle AgedPrevalenceRetrospective StudiesUnited Statescritical illnessdemographicsintensive care unitsprevalencesubstance use

Identifiers

PMID40736366
PMCPMC13034859

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.