ArticleHuman brain mapping2025
Data-Driven Approach to Dynamic Resting State Functional Connectivity in Post-Traumatic Stress Disorder: An ENIGMA-PGC PTSD Study.
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- Data-Driven Approach to Dynamic Resting State Functional Connectivity in Post-Traumatic Stress Disorder: An ENIGMA-PGC PTSD Study.Human brain mapping · 2025Article
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Authors and funding
75 authors.
Carissa W TomasDivision of Epidemiology and Social Sciences, Institute of Health and Equity, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.ORCID 0000-0002-9199-8632
Jacklynn M FitzgeraldDepartment of Psychology, Marquette University, Milwaukee, Wisconsin, USA.ORCID 0000-0002-6076-4067
C Lexi BairdBrain Imaging and Analysis Center, Duke University, Durham, North Carolina, USA.
Courtney C HaswellBrain Imaging and Analysis Center, Duke University, Durham, North Carolina, USA.
Chadi G AbdallahDivision of Psychiatry, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0001-5783-6181
Michael AngstadtDepartment of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA.
Justin T BakerDepartment of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA.
Hannah BergDepartment of Psychology, University of Minnesota, Minneapolis, Minnesota, USA.
Jennifer U BlackfordDepartment of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Josh CislerDepartment of Psychiatry, University of Texas at Austin, Austin, Texas, USA.
Andrew S CottonDepartment of Psychiatry, University of Toledo, Toledo, Ohio, USA.
Judith K DanielsDepartment of Clinical Psychology, University of Groningen, Groningen, The Netherlands.
Nicholas D DavenportMinneapolis VA Health Care System, Minneapolis, Minnesota, USA.
Richard J DavidsonCenter for Healthy Minds, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Terri A deRoon-CassiniComprehensive Injury Center, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Seth G DisnerMinneapolis VA Health Care System, Minneapolis, Minnesota, USA.
Wissam El HageUMR1253, Université de Tours, INSERM, Tours, France.
Negar FaniDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA.
Jessie L FrijlingAmsterdam UMC University of Amsterdam, Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands.
Evan M GordonDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Daniel W GrupeDepartment of Psychiatry, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Xiaofu HeNew York State Psychiatric Institute, New York, New York, USA.
Ryan HerringaSchool of Medicine and Public Health, University of Wisconsin Madison, Madison, Wisconsin, USA.
David HofmannInstitute of Medical Psychology and Systems Neuroscience, University of Münster, Münster, Germany.ORCID 0000-0003-3494-634X
Ashley A HugginsBrain Imaging and Analysis Center, Duke University, Durham, North Carolina, USA.
Ahmed HussainBrain Imaging and Analysis Center, Duke University, Durham, North Carolina, USA.
Jonathan IpserSA MRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Neda JahanshadImaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, California, USA.
Tanja JovanovicDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA.
Milissa L KaufmanDepartment of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA.
Yoojean KimNew York State Psychiatric Institute, New York, New York, USA.
Anthony KingDepartment of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA.
Saskia B J KochAmsterdam UMC University of Amsterdam, Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands.
Sheri KoopowitzSA MRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Amit LazarovTel-Aviv University, Tel Aviv-Yafo, Israel.
Lauren A M LeboisDepartment of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA.
Isreal LiberzonDepartment of Psychiatry, Texas A&M University, Bryan, Texas, USA.
Shmuel LissekDepartment of Psychology, University of Minnesota, Minneapolis, Minnesota, USA.
Antje MantheyUniversity Medical Centre Charité, Berlin, Germany.
Geoffrey MayVeterans Integrated Service Network-17 Center of Excellence for Research on Returning War Veterans, Waco, Texas, USA.
Katie A McLaughlinDepartment of Psychology, Harvard University, Cambridge, Massachusetts, USA.
Laura NawijnAmsterdam UMC University of Amsterdam, Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands.
Steven M NelsonVeterans Integrated Service Network-17 Center of Excellence for Research on Returning War Veterans, Waco, Texas, USA.
Yuval NeriaNew York State Psychiatric Institute, New York, New York, USA.
Jack B NitschkeDepartment of Psychology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Bunmi O OlatunjiDepartment of Psychology, Vanderbilt University, Nashville, Tennessee, USA.
Miranda OlffAmsterdam UMC University of Amsterdam, Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands.
Matthew PeverillDepartment of Psychology, University of Washington, Seattle, Washington, USA.
Yann QuidéSchool of Psychology, University of New South Wales (UNSW) Sydney, Sydney, New South Wales, Australia.
Orren RavidNew York State Psychiatric Institute, New York, New York, USA.
Kerry ResslerDepartment of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA.
Marisa RossNorthwestern Neighborhood and Network Initiative, Northwestern University Institute for Policy Research, Evanston, Illinois, USA.
Lauren E SalminenImaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, California, USA.ORCID 0000-0002-0684-9991
Kelly SambrookDepartment of Radiology, University of Washington, Seattle, Washington, USA.
Chiahao ShihDepartment of Psychiatry, University of Toledo, Toledo, Ohio, USA.
Anika SierkUniversity Medical Centre Charité, Berlin, Germany.
Scott R SponheimMinneapolis VA Health Care System, Minneapolis, Minnesota, USA.
Dan J SteinSA MRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Jennifer StevensDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA.
Thomas StraubeInstitute of Medical Psychology and Systems Neuroscience, University of Münster, Münster, Germany.
Benjamin Suarez-JimenezDepartment of Neuroscience, University of Rochester Medical Center, Rochester, New York, USA.
Paul M ThompsonImaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, California, USA.
Nic J A van der WeeDepartment of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands.
Steven J A van der WerffDepartment of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands.
Sanne J H van RooijDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA.
Mirjam van ZuidenAmsterdam UMC University of Amsterdam, Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands.
Dick J VeltmanAmsterdam UMC University of Amsterdam, Psychiatry, Amsterdam Neuroscience, Amsterdam, The Netherlands.
Robert R J M VermeirenDepartment of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands.
Henrik WalterUniversity Medical Centre Charité, Berlin, Germany.
Xin WangDepartment of Psychiatry, University of Toledo, Toledo, Ohio, USA.
Hong XieDepartment of Psychiatry, University of Toledo, Toledo, Ohio, USA.
Xi ZhuNew York State Psychiatric Institute, New York, New York, USA.
Sigal Zilcha-ManoUniversity of Haifa, Haifa, Israel.
Christine L LarsonDepartment of Psychology, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, USA.
Rajendra MoreyBrain Imaging and Analysis Center, Duke University, Durham, North Carolina, USA.
Funding
WISCONSIN CENTER ON MENTAL RETARDATION: CORE SUPPORTP30HD003352 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI DAVIDSON, RICHARD J · 1985 to 2015
$25.2MTRAINING PROGRAM IN EMOTION RESEARCHT32MH018931 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI Richard J Davidson · 1989 to 2026
$11.6MNeural Substrates of Affective Style and Emotion RegulationR01MH043454 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI DAVIDSON, RICHARD J, SCHAEFER, STACEY M · 1989 to 2022
$9.6MGenetic and Trauma-Related Risk Factors for PTSDR01MH071537 · NIMH · EMORY UNIVERSITY · PI RESSLER, KERRY J. · 2005 to 2014
$8.5MTrauma and Genomics Modulate Brain Structure across Common Psychiatric DisordersR01MH111671 · NIMH · DUKE UNIVERSITY · PI MARK W LOGUE, RAJENDRA A MOREY · 2017 to 2026
$4.4MMultimodal Approaches to Neurobiology of Traumatic DissociationR01MH119227 · NIMH · MCLEAN HOSPITAL · PI KAUFMAN, MILISSA L · 2020 to 2024
$3.7MGlucocorticoid modulation of contextual processing and its neurocircuitry: Testing a new model of PTSD pathophysiologyR01MH113574 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ABELSON, JAMES L, LIBERZON, ISRAEL · 2018 to 2022
$3.3MAcute Neurocognitive-affective Predictors of Chronic Post-trauma OutcomesR01MH106574 · NIMH · UNIVERSITY OF WISCONSIN MILWAUKEE · PI LARSON, CHRISTINE L · 2015 to 2019
$3.1MUsing novel virtual reality tasks to identify neural mechanisms of discrimination learning in PTSDR01MH131532 · NIMH · UNIVERSITY OF ROCHESTER · PI Benjamin Suarez-Jimenez · 2023 to 2026
$2.7MThe plasticity of well-being: A research network to define, measure and promote human flourishingU24AT011289 · NCCIH · UNIVERSITY OF WISCONSIN-MADISON · PI DAVIDSON, RICHARD J · 2021 to 2024
$2.4MNeural Signature of Fear Overgeneralization in Trauma Exposed AdultsR01MH105355 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI NERIA, YUVAL Y · 2015 to 2018
$1.7MEffect of TMS on PTSD Neuroimaging and Psychophysiological BiomarkersK01MH121653 · NIMH · EMORY UNIVERSITY · PI VAN ROOIJ, SANNE JH · 2020 to 2024
$894kAcademic Medical Center Research Council 110614Dana FoundationDeutsche Forschungsgemeinschaft DA 1222/4-1Deutsche Forschungsgemeinschaft WA 1539/8-2German Research SocietyJulia Kasparian Fund for Neuroscience ResearchMcLean Hospital Trauma Scholars FundNational Alliance for Research on Schizophrenia and Depression 27040National Science Foundation Graduate Research FellowshipNCCIH NIH HHS U24 AT011289NICHD NIH HHS P30 HD003352NIMH NIH HHS K01 MH118428NIMH NIH HHS K01MH118428NIMH NIH HHS K01 MH118467NIMH NIH HHS K01MH118467NIMH NIH HHS K01 MH121653NIMH NIH HHS K01MH121653NIMH NIH HHS K01 MH122774NIMH NIH HHS K01MH122774NIMH NIH HHS K23 MH101380NIMH NIH HHS MH071537NIMH NIH HHS MH098212NIMH NIH HHS MH101380NIMH NIH HHS R01 MH043454NIMH NIH HHS R01 MH071537NIMH NIH HHS R01 MH105355NIMH NIH HHS R01MH105355-01ANIMH NIH HHS R01 MH106574NIMH NIH HHS R01 MH111671NIMH NIH HHS R01 MH113574NIMH NIH HHS R01MH113574NIMH NIH HHS R01 MH119227NIMH NIH HHS R01MH119227NIMH NIH HHS R01 MH131532NIMH NIH HHS R01MH131532NIMH NIH HHS R21 MH098212NIMH NIH HHS R21 MH112956NIMH NIH HHS R21MH112956NIMH NIH HHS R21 MH125277NIMH NIH HHS R56 MH071537NIMH NIH HHS RO1 MH111671NIMH NIH HHS T32 MH018931PHRC, Foundation Pierre DenikerSAMRC Unit on Risk & Resilience in Mental DisordersVA National Center for PTSDVISN17 Center of Excellence Pilot fundingVISN6 MIRECCWaisman Center from the National Institute of Child Health and Human Development P30-HD003352ZonMw 40-00812-98-10041
Abstract
Using functional magnetic resonance imaging (fMRI), symptoms of posttraumatic stress disorder (PTSD) have been associated with aberrations in brain networks in the absence of a given cognitive demand or task, called resting-state networks. Prior work has focused on disruption in the static functional connectivity (FC) among specific regions constrained by a priori hypotheses. However, dynamic FC, an approach that examines brain network characteristics over time, may provide a more sensitive measure to understand the network properties underlying dysfunction in PTSD. Further, using a data-driven analytic approach may reveal the contribution of other larger network disturbances beyond those revealed by hypothesis-driven examinations of ROIs or canonical networks. Therefore, the current study used group independent components analysis (ICA) and graph theory principles to identify, characterize, and subsequently compare brain network dynamics and recurrent connectivity states in a large sample of trauma exposed individuals (N = 1035) with and without PTSD from the ENIGMA-PGC PTSD workgroup. Neither static FC nor dynamic FC results showed robust differences between groups. There were also no group differences in dwell time or number of transitions of recurrent connectivity states. This multi-cohort sample with heterogenous trauma types and demographic features offers a significantly larger scale approach than prior literature with smaller homogenous trauma cohorts. Heterogeneity of PTSD, especially within diffuse brain networks, may not be captured by evaluating only diagnostic groups, further work should be done to evaluate brain network dynamics with respect to specific symptom profiles and trauma types.
Indexed as
BrainConnectomeNerve NetStress Disorders, Post-TraumaticAdultFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedYoung Adult
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