Evidence map›Paper›PMID 40736257›Full record

ReviewJournal of virology2025

Cytomegalovirus latency-the sum of subtleties.

Meaghan H Hancock, Patrizia Caposio, Donna Collins-McMillen, Nicole L Diggins, Byeong-Jae Lee, Samuel Medica, Daniel N Streblow, Timothy White, Andrew D Yurochko, Felicia Goodrum

Abstract readReview
In one paragraph

Review in Journal of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Mechanisms and Determinants of CMV Reactivation in Kidney Transplantation.International journal of molecular sciences · 2026
    Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Meaghan H HancockVaccine and Gene Therapy Institute, Oregon Health and Science Institute, Beaverton, Oregon, USA.ORCID 0000-0003-2945-0147
Patrizia CaposioVaccine and Gene Therapy Institute, Oregon Health and Science Institute, Beaverton, Oregon, USA.
Donna Collins-McMillenDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA.
Nicole L DigginsVaccine and Gene Therapy Institute, Oregon Health and Science Institute, Beaverton, Oregon, USA.ORCID 0000-0001-8007-7865
Byeong-Jae LeeDepartment of Microbiology and Immunology, Louisiana State University Health Sciences Center, Shreveport, Louisiana, USA.
Samuel MedicaVaccine and Gene Therapy Institute, Oregon Health and Science Institute, Beaverton, Oregon, USA.
Daniel N StreblowVaccine and Gene Therapy Institute, Oregon Health and Science Institute, Beaverton, Oregon, USA.ORCID 0000-0002-6828-2492
Timothy WhiteDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA.
Andrew D YurochkoDepartment of Microbiology and Immunology, Louisiana State University Health Sciences Center, Shreveport, Louisiana, USA.ORCID 0000-0002-6452-5813
Felicia GoodrumDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA.ORCID 0000-0002-6646-7290

Funding

The Administrative CoreP01AI127335 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI DANIEL N STREBLOW, ANDREW D YUROCHKO · 2017 to 2026
$24.6M
Project 4-Tracking cytomegalovirus-primed long-lived NK cells in salivary glandP20GM134974 · NIGMS · LOUISIANA STATE UNIV HSC SHREVEPORT · PI ANDREW D YUROCHKO · 2021 to 2026
$15.0M
Mechanisms of Human Cytomegalovirus Latency in Primary Human Hematopoietic CellsR01AI079059 · NIAID · UNIVERSITY OF ARIZONA · PI GOODRUM, FELICIA D · 2008 to 2018
$4.4M
Molecular Aspects of Cytomegalovirus LatencyR37AI021640 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI HANCOCK, MEAGHAN H · 2018 to 2024
$4.0M
Mechanisms of Human Cytomegalovirus Latency in Primary Human Hematopoietic CellsR37AI079059 · NIAID · UNIVERSITY OF ARIZONA · PI Felicia D Goodrum · 2019 to 2026
$3.3M
Host DNA repair pathways in human cytomegalovirus replicationR01AI177392 · NIAID · UNIVERSITY OF ARIZONA · PI Giovanni Bosco, Felicia D Goodrum · 2023 to 2026
$3.0M
Virus-host interactions regulating innate signaling for human cytomegalovirus latencyR01AI169728 · NIAID · UNIVERSITY OF ARIZONA · PI Felicia D Goodrum · 2022 to 2026
$1.9M
HCMV stimulation of interferon signaling to promote viral gene expression and latencyF32AI186281 · NIAID · UNIVERSITY OF ARIZONA · PI Timothy M White · 2024 to 2026
$154k
NIAID NIH HHS F32 AI186281NIAID NIH HHS P01 AI127335NIAID NIH HHS R01 AI079059NIAID NIH HHS R01 AI169728NIAID NIH HHS R01 AI177392NIAID NIH HHS R37 AI021640NIAID NIH HHS R37 AI079059NIGMS NIH HHS P20 GM134974NIH HHS AI079059NIH HHS AI127335NIH HHS AI169728NIH HHS AI186281NIH HHS GM134974
6 · The paper itself

Abstract

Human cytomegalovirus (HCMV) is a betaherpesvirus, which, like all herpesviruses, establishes a life-long latent infection while retaining the ability to reactivate its replicative program. While HCMV likely reactivates frequently and sporadically in healthy individuals and typically without disease, reactivation poses a serious disease threat in the immunocompromised. The latent program of HCMV is complex and has been challenging to define due to limitations in appropriate experimental model systems related to virus-host species specificity, limited identification of

Indexed as

CytomegalovirusCytomegalovirus InfectionsVirus LatencyAnimalsDisease Models, AnimalHumansVirus Activationcytomegalovirusherpesviruslatencyvirus-host interactions

Identifiers

PMID40736257
PMCPMC12363206

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.