ArticlemBio2025
Gentamicin induction of the gonococcal
Concerta L Holley, Vijaya Dhulipala, Adriana Le Van, Jacqueline T Balthazar, Vincent J Oliver, Ann E Jerse, William M Shafer
Abstract read
In one paragraphArticle in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
7 authors.
Concerta L HolleyDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID 0000-0003-0177-4270 Vijaya DhulipalaDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA.
Adriana Le VanDepartment of Microbiology and Immunology, Uniformed Services University, Bethesda, Maryland, USA.
Jacqueline T BalthazarDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA.
Vincent J OliverDepartment of Microbiology and Immunology, Uniformed Services University, Bethesda, Maryland, USA.
Ann E JerseDepartment of Microbiology and Immunology, Uniformed Services University, Bethesda, Maryland, USA.
William M ShaferDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID 0000-0001-9303-8777 Funding
Winship Cancer Institute Cancer Center Support GrantP30CA138292 · NCI · EMORY UNIVERSITY · PI Ragini Reiney Kudchadkar · 2009 to 2026
$47.5MGONOCOCCI: GENETICS OF RESISTANCE TO PMN PROTEINSR01AI021150 · NIAID · EMORY UNIVERSITY · PI SHAFER, WILLIAM MAURICE · 1985 to 2025
$5.5MGonococci: Genetics of Resistance to PMN ProteinsR37AI021150 · NIAID · EMORY UNIVERSITY · PI SHAFER, WILLIAM MAURICE · 2010 to 2019
$3.9MFunction and regulation of the intrinsic antibiotic resistome of Neisseria gonorrhoeaeR01AI147609 · NIAID · EMORY UNIVERSITY · PI SHAFER, WILLIAM MAURICE · 2019 to 2023
$2.3MBLRD VA IK6 BX005390NCI NIH HHS P30 CA138292NIAID NIH HHS R01 AI021150NIAID NIH HHS R01 AI147609NIAID NIH HHS R37 AI021150NIH HHS AI021150NIH HHS AI147609-05
6 · The paper itselfAbstract
The continued emergence of IMPORTANCE: During antibiotic treatment, bacteria can be exposed to sub-lethal levels that could serve as a stress signal, resulting in changes in gene expression. The continued emergence of multi-drug-resistant strains of Ng has rekindled interest in expanded use of gentamicin (Gen) for the treatment of gonorrheal infections. We report that sub-lethal levels of Gen can influence levels of Ng transcripts, including that of the gonococcal
Indexed as
Anti-Bacterial AgentsBacterial ProteinsBiofilmsGene Expression Regulation, BacterialGentamicinsNeisseria gonorrhoeaeToxin-Antitoxin SystemsAnimalsFemaleGonorrheaMiceAnti-Bacterial AgentsBacterial ProteinsGentamicinsbiofilmgentamicinNeisseria gonorrhoeaestress responsetoxin-antitoxin
Identifiers
PMID40736253
PMCPMC12421842
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