Evidence map›Paper›PMID 40736236›Full record

ArticleMicrobiology spectrum2025

An antisense peptide-conjugated peptide nucleic acid (PPNA) for peptidoglycan recycling inhibition reduces AmpC hyperproduction and β-lactam resistance in

Maria Escobar-Salom, Isabel M Barceló, Jordi Sansó-Sastre, Gabriel Torrens, Elena Jordana-Lluch, Bartolomé Moyà, Antonio Oliver, Carlos Juan

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In one paragraph

Article in Microbiology spectrum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Maria Escobar-SalomARPBIG group, Health Research Institute of the Balearic Islands (IdISBa), Palma, Spain.
Isabel M BarcelóARPBIG group, Health Research Institute of the Balearic Islands (IdISBa), Palma, Spain.
Jordi Sansó-SastreARPBIG group, Health Research Institute of the Balearic Islands (IdISBa), Palma, Spain.
Gabriel TorrensDepartment of Molecular Biology and Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå Centre for Microbial Research (UCMR), Umeå University, Umeå, Sweden.
Elena Jordana-LluchARPBIG group, Health Research Institute of the Balearic Islands (IdISBa), Palma, Spain.ORCID 0000-0002-1115-2048
Bartolomé MoyàARPBIG group, Health Research Institute of the Balearic Islands (IdISBa), Palma, Spain.
Antonio OliverARPBIG group, Health Research Institute of the Balearic Islands (IdISBa), Palma, Spain.ORCID 0000-0001-9327-1894
Carlos JuanARPBIG group, Health Research Institute of the Balearic Islands (IdISBa), Palma, Spain.ORCID 0000-0002-1402-3516

Funding

Govern de les Illes Balears FPI/2206/2019Instituto de Salud Carlos III CB21/13/00099Instituto de Salud Carlos III FI19/00004Instituto de Salud Carlos III PI21/00753Instituto de Salud Carlos III PI24/00010Ministerio de Ciencia, Innovación y Universidades CNS2023-144168Ministerio de Ciencia, Innovación y Universidades IJC2019-038836-I
6 · The paper itself

Abstract

We performed a proof-of-concept study to validate a peptide-conjugated peptide nucleic acid (PPNA) directed to inhibit peptidoglycan recycling as strategy to reduce AmpC hyperproduction and β-lactam resistance in

Indexed as

Anti-Bacterial AgentsBacterial Proteinsbeta-Lactamasesbeta-Lactam ResistancePeptide Nucleic AcidsPeptidoglycanPseudomonas aeruginosaA549 Cellsbeta-LactamsCeftazidimeHumansMicrobial Sensitivity TestsPseudomonas InfectionsAmpC beta-lactamasesAnti-Bacterial AgentsBacterial Proteinsbeta-Lactamasesbeta-LactamsCeftazidimePeptide Nucleic AcidsPeptidoglycanAmpC β-lactamaseceftazidimeNagZpeptide-conjugated peptide nucleic acid (PPNA)peptidoglycan recyclingPseudomonas aeruginosa

Identifiers

PMID40736236
PMCPMC12403870

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.