Evidence map›Paper›PMID 40736210›Full record

ArticleJournal of surgical oncology2025

Implications of an Isolated Positive Vascular Groove After Whipple for Pancreatic Adenocarcinoma: A Single Institution, Retrospective Analysis.

Callie A Hlavin, Sebastiaan Ceuppens, Nikhil Tirukkovalur, Jiage Qian, Aatur D Singhi, Nathan Cook, Ibrahim Nassour, Kenneth K Lee, Amer H Zureikat, Alessandro Paniccia

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Callie A HlavinDepartment of Anesthesiology and Perioperative Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Sebastiaan CeuppensDivision of GI Surgical Oncology, UPMC Pancreatic Cancer Center, University of Pittsburgh Medical Center, UPMC Cancer Pavilion, Pittsburgh, PA, USA.
Nikhil TirukkovalurDivision of GI Surgical Oncology, UPMC Pancreatic Cancer Center, University of Pittsburgh Medical Center, UPMC Cancer Pavilion, Pittsburgh, PA, USA.
Jiage QianDivision of GI Surgical Oncology, UPMC Pancreatic Cancer Center, University of Pittsburgh Medical Center, UPMC Cancer Pavilion, Pittsburgh, PA, USA.
Aatur D SinghiDepartment of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Nathan CookDepartment of Pathology, New York University Grossman School of Medicine, New York, NY, USA.
Ibrahim NassourDivision of GI Surgical Oncology, UPMC Pancreatic Cancer Center, University of Pittsburgh Medical Center, UPMC Cancer Pavilion, Pittsburgh, PA, USA.
Kenneth K LeeDivision of GI Surgical Oncology, UPMC Pancreatic Cancer Center, University of Pittsburgh Medical Center, UPMC Cancer Pavilion, Pittsburgh, PA, USA.
Amer H ZureikatDivision of GI Surgical Oncology, UPMC Pancreatic Cancer Center, University of Pittsburgh Medical Center, UPMC Cancer Pavilion, Pittsburgh, PA, USA.
Alessandro PanicciaDivision of GI Surgical Oncology, UPMC Pancreatic Cancer Center, University of Pittsburgh Medical Center, UPMC Cancer Pavilion, Pittsburgh, PA, USA.ORCID https://orcid.org/0000-0001-7047-1711

Funding

Research Training in Anesthesiology and Pain MedicineT32GM075770 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI YAN XU · 2007 to 2026
$4.8M
NIGMS NIH HHS T32 GM075770This study was supported in part by the grant T32GM075770 from the National Institutes of Health grant (PI: Yan Xu, PhD).
6 · The paper itself

Abstract

BACKGROUND AND

objectiveThe vascular groove (VG) is no longer considered a resection margin but rather a surface of involvement. The clinical significance of an isolated VG+ remains debated. Therefore, this study evaluates the impact of isolated VG+, with or without vein resection, on overall survival (OS) and disease-free survival (DFS) following pancreaticoduodenectomy (PD) for pancreatic ductal adenocarcinoma (PDAC).

methodsA retrospective analysis of 247 patients (2006-2019) was conducted. Patients were categorized into three groups: R0 resection (tumor > 1 mm from all margins, n = 168), VG+ without vein invasion (+VGnoVI, n = 66), and positive vein involvement with direct tumor invasion into the vein wall (+VGwithVI) (n = 13). Kaplan-Meier estimates assessed OS and DFS, while multivariable analyses identified recurrence and survival predictors.

results+VGnoVI group showed higher rates of local recurrence (OR 2.68, p = 0.002) compared to the R0 group. However, no significant differences were observed in DFS (R0: 17 months; +VGnoVI: 18 months; +VGwithVI: 21 months, p = 0.68) or OS (R0: 27 months; +VGnoVI: 29 months; +VGwithVI: 30 months, p = 0.98) across groups.

conclusionsA positive vascular groove, whether isolated or associated with vein invasion, does not compromise OS or DFS compared to R0 resections.

Indexed as

AdenocarcinomaCarcinoma, Pancreatic DuctalNeoplasm Recurrence, LocalPancreatic NeoplasmsPancreaticoduodenectomyAgedAged, 80 and overFemaleFollow-Up StudiesHumansMaleMargins of ExcisionMiddle AgedNeoplasm InvasivenessPrognosisRetrospective Studiesdisease‐free survivaloverall survivalpancreatic ductal adenocarcinomapositive marginvascular groove

Identifiers

PMID40736210
PMCPMC12455548

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.