SynthesisJournal of gastroenterology and hepatology2025
Impact of Different Modalities of Radiotherapy in Locally Advanced Pancreatic Cancer: A Review and Meta-Analysis.
Synthesis in Journal of gastroenterology and hepatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Impact of Different Modalities of Radiotherapy in Locally Advanced Pancreatic Cancer: A Review and Meta-Analysis.Journal of gastroenterology and hepatology · 2025Pooled it
- The role of chemoradiotherapy after induction in locally advanced pancreatic cancer: lessons learnt from CONKO-007.Journal of gastrointestinal oncology · 2026Article
- Review
- Survival benefit of particle chemoradiotherapy in locally advanced unresectable pancreatic cancer: a systematic review and meta-analysis.Therapeutic advances in gastroenterology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pancreatic ductal adenocarcinoma (PDAC) remains a high-mortality cancer in dire need of more effective therapeutic strategies. Six randomized controlled trials have compared chemotherapy with chemoradiotherapy in patients with locally advanced pancreatic cancer (LAPC), but these trials only involved conventional external beam radiotherapy. Over the last decade, stereotactic body radiation therapy (SBRT) has risen to prominence over conventional external beam radiotherapy. Moreover, endoscopic ultrasound (EUS)-guided brachytherapy has been used in a trial setting, though it is not routinely used in LAPC. In this review, we report a meta-analysis of randomized controlled trials that have compared chemotherapy with chemoradiotherapy and review two-arm trials assessing survival outcomes with chemotherapy and SBRT over chemotherapy only. We also review the increasing role of EUS-guided brachytherapy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.