Observational studyJournal of the American Heart Association2025
Left Atrial Volumetric/Mechanical Coupling Index in Heart Failure With Preserved Ejection Fraction.
Observational study in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- Beyond Conventional Echocardiography: The Emerging Role of Left Atrioventricular Coupling Indexes in Chronic Chagas Disease.Echocardiography (Mount Kisco, N.Y.) · 2026Article
- Prognostic value of left atrioventricular coupling index in non-ischemic dilated cardiomyopathy: a cardiovascular magnetic resonance study.BMC cardiovascular disorders · 2026Article
- Role of imaging techniques in monitoring atrial cardiomyopathy and atrial failure: a scientific statement.ESC heart failure · 2026Review
- The Evolution of Heart Failure Assessment in Asia.JACC. Asia · 2025Article
- Left Atrial Volumetric/Mechanical Coupling Index Is Ready for Prime Time Across Clinical Scenarios.Journal of the American Heart Association · 2025Article
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Authors and funding
19 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLeft atrial (LA) dysfunction is common in heart failure with preserved ejection fraction (HFpEF). The LA volumetric/mechanical coupling index (LACI), calculated as the LA volume index divided by the late diastolic mitral annular velocity (a'), is a recently advocated parameter reflecting LA contractile function based on the atrial Frank-Starling mechanism. An elevated LACI signifies impaired mechanical performance despite greater atrial volume, indicating volumetric/mechanical uncoupling. Its associations with echocardiographic indices and prognostic significance in HFpEF remain unclear.
methodsThis study included 562 patients from the PURSUIT-HFpEF (Prospective Multicenter Observational Study of Patients With Heart Failure With Preserved Ejection Fraction) registry, a prospective multicenter registry for HFpEF. LACI was calculated and categorized into quartiles. Associations with echocardiographic indices and clinical outcomes were examined.
resultsLA volume index and late diastolic mitral annular velocity were negatively correlated (
conclusionsIn patients with HFpEF, LA mechanical activity decreased with LA enlargement, suggesting volumetric/mechanical uncoupling inherent in this cohort. LACI may serve as a clinically relevant index for risk stratification of cardiovascular death or rehospitalization for heart failure in patients with HFpEF. REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: UMIN000021831.
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