Evidence map›Paper›PMID 40736067›Full record

ArticleNanomedicine (London, England)2025

Formation and evaluation of docetaxel and triptolide polymer micelles for anti-cancer activity.

Jingmei Zhou, Min Lin, Yan Mo, Ruiyue Dang, Jin Zhou, Chengmin Li, Xin Deng, Alaa Aldeen Alsaeedi, Yingqi Zhao, Juan Huang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanomedicine (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jingmei ZhouDepartment of Clinical Medicine, Medical College of Xiangya, Central South University, Changsha, China.ORCID 0000-0003-0716-8538
Min LinDepartment of Oncology and Institute of Medical Sciences, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.ORCID 0000-0002-8427-1777
Yan MoDepartment of Oncology and Institute of Medical Sciences, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
Ruiyue DangDepartment of Oncology and Institute of Medical Sciences, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
Jin ZhouDepartment of Oncology and Institute of Medical Sciences, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
Chengmin LiDepartment of Pathology, Xiangya Hospital, Central South University, Changsha, China.
Xin DengDepartment of Clinical Medicine, Medical College of Xiangya, Central South University, Changsha, China.
Alaa Aldeen AlsaeediDepartment of Oncology and Institute of Medical Sciences, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
Yingqi ZhaoDepartment of Oncology and Institute of Medical Sciences, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
Juan HuangDepartment of Breast Surgery, Multidisciplinary Breast Cancer Center, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
Lijuan MaDepartment of Otolaryngology-Head and Neck Surgery, Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University), Changsha, China.ORCID 0009-0008-5356-9133
Xueping FengDepartment of Oncology and Institute of Medical Sciences, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.ORCID 0000-0003-0481-3853
Yong LiuDepartment of Otolaryngology-Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, China.ORCID 0000-0001-5102-0309
Yunyun WangDepartment of Otolaryngology-Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, China.ORCID 0000-0002-9885-2599

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo develop docetaxel (DTX) and triptolide (TPL) polymer micelles (DTX/TPL-PMs) with synergistic anti-cancer effect and to evaluate their anti-cancer activity.

methodsDTX/TPL-PMs were prepared by thin-film hydration. The drug loading (DL%), encapsulation efficiency (EE%), and cumulative release rate (CR%) were determined using HPLC. The anti-cancer activity was assessed using CCK-8, inverted microscopy, and laser scanning confocal microscope (LSCM).

resultsDTX/TPL-PMs exhibited the average particle size of 178.58 ± 1.66 nm with a polydispersity index (PDI) of 0.102 ± 0.018 and a zeta potential of 1.19 ± 0.12 mV. These micelles showed a high EE% (89.43%) and a DL% (5.21%). In vitro release studies of DTX/TPL-PMs revealed that the loaded drug exhibited a slow-release phase in physiological fluids and a rapid-release phase under acidic conditions. Compared with the free DTX/TPL drugs, DTX/TPL-PMs were more readily taken up by cancer cells. The cytotoxicity of DTX/TPL-PMs was significantly higher than that of the free drugs, which showed stronger growth inhibitory effects and higher apoptosis rates in cancer cells.

conclusionThe research results demonstrate that DTX/TPL-PMs enhance the therapeutic efficacy against malignancies, while reducing adverse effects. It holds potential as an effective nanotherapeutic for combination chemotherapy and represents a promising clinical strategy.

Indexed as

Antineoplastic AgentsDiterpenesDocetaxelPhenanthrenesPolymersTaxoidsCell Line, TumorCell SurvivalDrug CarriersDrug LiberationEpoxy CompoundsHumansMicellesParticle SizeAntineoplastic AgentsDiterpenesDocetaxelDrug CarriersEpoxy CompoundsMicellesPhenanthrenesPolymersTaxoidstriptolidecombination chemotherapyDocetaxelnano deliverypolymer micellestriptolide

Identifiers

PMID40736067
PMCPMC12330271

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.