ArticleAnatolian journal of cardiology2025
From Gut to Heart: Mendelian Randomization Study Reveals the Causal Relationship Between Gut Microbiota and N-Terminal Pro-B-Type Natriuretic Peptide.
Article in Anatolian journal of cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThis study aimed to clarify the potential causal relationship between gut microbiota (GM) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) using Mendelian randomization (MR) analysis.
methodsGenome-wide association study of intestinal flora and NT-proBNP was conducted, and the instrumental variables (IVs) were screened out to assess the causal association between intestinal flora and NT-proBNP. The 2-sample MR analysis was performed using the inverse variance weighted (IVW), MR-Egger, weighted model and simple model methods, respectively, to assess the causal association between intestinal flora and NT-proBNP using the odds ratio. Sensitivity analyses were also performed using the leave-one-out method and MR-Egger intercept test. The MR-PRESSO global test was used to detect horizontal pleiotropy, and Cochran Q was used to detect heterogeneity. Finally, forest plots, scatter plots, and funnel plots of the IVs were generated.
resultsBased on the IVW method, a total of 9 out of 104 GM genera were identified as causally associated with NT-proBNP levels (P < .05). The genera Holdemanella (β = -0.19, 95% CI: -0.36 to -0.01, P = .037), Coprococcus 2 (β = -0.27, 95% CI: -0.54 to 0.00, P = .047), Ruminococcaceae UCG 004 (β = -0.23, 95% CI: -0.45 to -0.02, P = .032), and Alistipes (β = -0.29, 95% CI: -0.55 to -0.03, P = .031) were negatively associated with NT-proBNP; genera Actinomyces (β = 0.22, 95% CI: 0.01-0.44, P = .042), Lachnospiraceae UCG 008 (β = 0.27, 95% CI: 0.1-0.44, P = .002), Eubacterium fissicatena group (β = 0.17, 95%CI: 0.01-0.32, P = .033), Eubacterium rectale group (β = 0.40, 95% CI: 0.13-0.67, P = .003), and Eubacterium ventriosum group (β = 0.26, 95% CI: 0.02-0.49, P = .032) were positively associated with NT-proBNP. In addition, the results of the sensitivity analysis of the leave-one-out method were stable, there was no horizontal multiplicity in the MR-Egger intercept test and the MR-PRESSO global test, and there was no heterogeneity in the Cochran Q-test.
conclusionsThe study found the causal relationship between GM and NT-proBNP. As a clinical predictor of heart failure, NT-proBNP levels could potentially be modulated through clinical interventions involving GM, further reducing the risk of heart failure.
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