Evidence map›Paper›PMID 40735939›Full record

ArticleACS chemical biology2025

Select Azo Compounds Post-translationally Modulate HTRA1 Abundance and Activity Potentially through Interactions at the Trimer Interface.

John D Hulleman, Seungje Jeon, Sofia Bali, Sophia M DiCesare, Ali Abbas, Steffi Daniel, Antonio J Ortega, Gracen E Collier, Julian Yang, Archishman Bhattacharyaa and 3 more

Abstract read
In one paragraph

Article in ACS chemical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

John D HullemanDepartment of Ophthalmology and Visual Neurosciences, University of Minnesota, 2001 Sixth St. SE, Minneapolis, Minnesota 55455, United States.ORCID 0000-0001-8149-656X
Seungje JeonDepartment of Ophthalmology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390, United States.
Sofia BaliCenter for Alzheimer's and Neurodegenerative Diseases, O'Donnell Brain Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390, United States.
Sophia M DiCesareDepartment of Ophthalmology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390, United States.
Ali AbbasDepartment of Ophthalmology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390, United States.
Steffi DanielDepartment of Ophthalmology and Visual Neurosciences, University of Minnesota, 2001 Sixth St. SE, Minneapolis, Minnesota 55455, United States.
Antonio J OrtegaDepartment of Ophthalmology and Visual Neurosciences, University of Minnesota, 2001 Sixth St. SE, Minneapolis, Minnesota 55455, United States.
Gracen E CollierDepartment of Ophthalmology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390, United States.
Julian YangDepartment of Ophthalmology and Visual Neurosciences, University of Minnesota, 2001 Sixth St. SE, Minneapolis, Minnesota 55455, United States.
Archishman BhattacharyaaDepartment of Ophthalmology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390, United States.
Melissa K McCoyDepartment of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390, United States.
Lukasz A JoachimiakCenter for Alzheimer's and Neurodegenerative Diseases, O'Donnell Brain Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390, United States.ORCID 0000-0003-3061-5850
Bruce A PosnerDepartment of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390, United States.

Funding

UT Southwestern Medical Center Simmons Comprehensive Cancer CenterP30CA142543 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Kathryn Ann O'Donnell · 2010 to 2026
$53.7M
Stem Cell, Organoid and Cell Phenotyping ModuleP30EY030413 · NEI · UT SOUTHWESTERN MEDICAL CENTER · PI W MATTHEW PETROLL · 2019 to 2026
$5.9M
Functional Ocular Chemoproteomics for Retinal Biology Insight and in vivo Enzyme ActivityR21EY032693 · NEI · UT SOUTHWESTERN MEDICAL CENTER · PI HULLEMAN, JOHN DOUGLAS · 2023 to 2024
$440k
Structural profiling of tauopathy seedsR01AG076459 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI Lukasz A. Joachimiak · 2026 to 2026
$415k
An acoustic droplet ejection liquid dipenser for our UTSW HTS CoreS10OD026758 · OD · UT SOUTHWESTERN MEDICAL CENTER · PI POSNER, BRUCE ARTHUR · 2019 to 2019
$337k
T35 NEI Medical Student Summer Research TrainingT35EY026510 · NEI · UT SOUTHWESTERN MEDICAL CENTER · PI Benjamin Franklin Chong, DANIELLE M. ROBERTSON · 2018 to 2026
$99k
Inhibiting fibrillation of Tau through changes in local intramolecular interactionsF31NS127513 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI BALI, SOFIA · 2022 to 2023
$77k
NCI NIH HHS P30 CA142543NEI NIH HHS P30 EY030413NEI NIH HHS R21 EY032693NEI NIH HHS T35 EY026510NIA NIH HHS R01 AG076459NIH HHS S10 OD026758NINDS NIH HHS F31 NS127513
6 · The paper itself

Abstract

High-temperature requirement protein A1 (HTRA1) is a secreted serine protease with diverse substrates, including extracellular matrix proteins, proteins involved in amyloid deposition, and growth factors. Accordingly, HTRA1 has been implicated in a variety of neurodegenerative diseases including a leading cause of blindness in the elderly, age-related macular degeneration (AMD). In fact, genomewide association studies have identified that the 10q26 locus that contains

Indexed as

Azo CompoundsHigh-Temperature Requirement A Serine Peptidase 1Protein Processing, Post-TranslationalCRISPR-Cas SystemsHumansMacular DegenerationRetinal Pigment EpitheliumAzo CompoundsHigh-Temperature Requirement A Serine Peptidase 1HTRA1 protein, human

Identifiers

PMID40735939
PMCPMC13420024

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.