ReviewJournal of cosmetic dermatology2025
Aging of the Human Lip: Current Knowledge and Clinical Implications.
Review in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Bullhorn and Beyond: Evidence-Based Review and Clinical Recommendations for Lip Lift Techniques.Journal of cosmetic dermatology · 2026Pooled it
- Targeting Circadian Rhythm for the Regulation of Skin Collagen Metabolism.Journal of cosmetic dermatology · 2026Article
- Aging of the Human Lip: Current Knowledge and Clinical Implications.Journal of cosmetic dermatology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundComprehensive exploration of lip aging remains limited due to anatomical complexity of the structure, with current investigations predominantly focusing on aspects such as dryness management, cheilitis prevention and treatment, and surgical lifts.
aimsThis article aims to review multiple aspects of lip aging and to explore anti-aging approaches for the lips, thereby providing actionable insights for the development of cosmetic lip care products.
methodsWe conducted a literature search in the PubMed database using keywords related to lip aging, and selected the most relevant articles for in-depth reading, summarization, and integration to form the content of this review.
resultsDue to the significant differences between lip and facial skin in terms of barrier function, melanin content, transepidermal absorption capacity, physiological activity frequency, and fat distribution, the aging characteristics of lips also exhibit uniqueness. At the same time, there are gender differences in lip aging manifestations, with women typically showing more noticeable perioral wrinkles compared to men.
conclusionsThe clinical manifestations and pathogenic mechanisms of lip aging differ significantly from those of facial aging, requiring distinct priorities in anti-aging product development. For the vermilion, the focus should be on barrier restoration, mild anti-aging approaches, and photoaging prevention. In contrast, perioral anti-aging may be addressed by inhibiting ECM degradation and enhancing tissue volume. Addressing gender differences can guide the development of anti-aging lip products tailored to women, while managing associated pigmentary changes offers a unique avenue for this purpose.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.