ArticleJournal of cachexia, sarcopenia and muscle2025
Reference Data and Predictors of HR-pQCT-Derived Muscle Density and Its Prediction of Physical Performance.
Article in Journal of cachexia, sarcopenia and muscle, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Leg muscle assessment by HR-pQCT and DXA: associations between imaging measures and muscle function in adults with obesity-a pilot study.JBMR plus · 2026Article
- Muscle Imaging Assessments in Sarcopenia: A Statement from China National Center for Orthopedics (NCO) and the East Meets West Action Group of the European Calcified Tissue Society (ECTS).Calcified tissue international · 2025Review
- Reference Data and Predictors of HR-pQCT-Derived Muscle Density and Its Prediction of Physical Performance.Journal of cachexia, sarcopenia and muscle · 2025Article
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Authors and funding
9 authors.
Funding
Abstract
backgroundThere is increasing awareness of a role for muscle composition in sarcopenia and cachexia. Computed tomography (CT)-based measures of muscle density (MusD) are commonly used to indicate composition, with a decrease in MusD reflecting an increase in muscle fat infiltration. The current study explored predictors of MusD acquired using high-resolution peripheral quantitative computed tomography (HR-pQCT) and whether MusD predicted physical performance. In addition, reference data for MusD were generated and applied.
methodsHR-pQCT scans performed in 1662 adults (aged 18-80 years) at 30% of bone length proximal from the distal end of the radius and tibia were analysed for forearm and leg MusD, respectively. Predictors of MusD were explored, and it was investigated whether MusD predicted physical performance. Centile curves were fit to the MusD data using the LMS approach to generate reference data, and a calculator was developed to enable computation of subject-specific standardised outcomes. The utility of the calculator was explored in validation cohorts of female collegiate-level athletes (n = 50) and individuals with chronic kidney disease (CKD) (n = 50).
resultsForearm and leg MusD were predicted by whole-body percent fat, sex and age. Forearm and leg MusD were 0.46 (~1.9%) and 0.60 mgHA/cm
conclusionsHR-pQCT acquired MusD provides a novel indicator of muscle composition which predicts physical function independent of muscle quantity (i.e., ALM/height
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