ArticleNanomedicine (London, England)2025
Dox-HCl and miR-145 co-delivery through CD44-targeted PEGylated liposomes inhibit Breast Cancer
Article in Nanomedicine (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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3 authors.
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Abstract
aimsThe aim of this study deals with integrating a CD44-targeting short peptide, A6 (KPSSPPEE) onto the PEGylated liposomes to enhance the in vitro anticancer activities of doxorubicin hydrochloride and tumor suppressor miR-145 mimics on triple-negative breast cancer.
methodsA CD44-targeting short peptide, A6 (KPSSPPEE) was integrated onto the optimized PEGylated liposomes, and its effects on cellular uptake, anti-proliferation, and anti-metastasis activities were assessed in triple-negative breast cancer, MDA-MB-231 cells.
resultsThe resulting formulation (A6-PEG-lipo-Dox-miR145) demonstrated enhanced cellular uptake by CD44-expressing MDA-MB-231 cells within 2 h of incubation. In vitro study showed that A6-PEG-lipo-Dox-miR145 exerted a greater anti-proliferative activity with higher selectivity (Dox-HCl IC
conclusionOur findings indicate that the incorporation of A6 peptide represents a simple and straightforward strategy to improve the targetability and therapeutic effects of PEGylated liposome, warranting further investigation.
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