ArticleCirculation research2025
Immunoregulatory Endothelial Cells Interact With T Cells After Myocardial Infarction.
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Article in Circulation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed.
- Endothelial cells modulate immune cell responses during atherosclerosis.Trends in immunology · 2026Review
- An epigenetic switch in vascular phenotype augments anti-tumor immunity.Angiogenesis · 2026Article
- Mechanisms, precision therapies, and technological frontiers in coronary atherosclerosis: a comprehensive review.Acta pharmacologica Sinica · 2026Review
- Defining the vascular niche of human adipose tissue across metabolic states.Nature metabolism · 2026Article
- Icariin-mediated structural stabilization of TNF-α triggers a pro-regenerative signaling switch for endothelial recovery after myocardial infarction.Frontiers in pharmacology · 2026Article
- From hemodynamic stress to inflammatory wall remodeling in intracranial aneurysms.Frontiers in molecular biosciences · 2026Review
- Immune Mechanisms in Myocardial Remodeling Following Myocardial Infarction: Focusing on Regulatory Networks of T Cell Responses.Journal of inflammation research · 2026Review
- Regulatory T cells in cardiac allograft vasculopathy: from mechanistic insights to clinical tolerance.Frontiers in immunology · 2026Review
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Authors and funding
35 authors.
Lukas S Tombor *Institute of Cardiovascular Regeneration (L.S.T., T.L., S.F.G., A.F., M.M., K.A.S., J.P., M.M.-R., L.-M.K., L.Z., L.S., B.S., D.R.M., D.J., H.K., M.-T.K., E.G.S., G.L., W.T.A., S.C., S.D.), Goethe University, Frankfurt, Germany.ORCID 0000-0002-5867-576X
Till Lautenschläger *Institute of Cardiovascular Regeneration (L.S.T., T.L., S.F.G., A.F., M.M., K.A.S., J.P., M.M.-R., L.-M.K., L.Z., L.S., B.S., D.R.M., D.J., H.K., M.-T.K., E.G.S., G.L., W.T.A., S.C., S.D.), Goethe University, Frankfurt, Germany.ORCID 0009-0003-8094-0245
Simone F GlaserInstitute of Cardiovascular Regeneration (L.S.T., T.L., S.F.G., A.F., M.M., K.A.S., J.P., M.M.-R., L.-M.K., L.Z., L.S., B.S., D.R.M., D.J., H.K., M.-T.K., E.G.S., G.L., W.T.A., S.C., S.D.), Goethe University, Frankfurt, Germany.ORCID 0000-0002-0808-2659
Ariane FischerInstitute of Cardiovascular Regeneration (L.S.T., T.L., S.F.G., A.F., M.M., K.A.S., J.P., M.M.-R., L.-M.K., L.Z., L.S., B.S., D.R.M., D.J., H.K., M.-T.K., E.G.S., G.L., W.T.A., S.C., S.D.), Goethe University, Frankfurt, Germany.ORCID 0000-0001-8074-3354
Maximilian MertenInstitute of Cardiovascular Regeneration (L.S.T., T.L., S.F.G., A.F., M.M., K.A.S., J.P., M.M.-R., L.-M.K., L.Z., L.S., B.S., D.R.M., D.J., H.K., M.-T.K., E.G.S., G.L., W.T.A., S.C., S.D.), Goethe University, Frankfurt, Germany.ORCID 0009-0001-4793-7146
Susanne S HilleDepartment of Internal Medicine V, University Hospital Schleswig-Holstein, University of Kiel, Germany (S.S.H., O.J.M.).ORCID 0000-0002-9809-4636
Oliver J MüllerDepartment of Internal Medicine V, University Hospital Schleswig-Holstein, University of Kiel, Germany (S.S.H., O.J.M.).ORCID 0000-0001-8223-2638
Christian KupattGerman Centre for Cardiovascular Research (DZHK), Munich (C. Kupatt, T.B.).ORCID 0000-0002-3611-1218
Tarik BozogluGerman Centre for Cardiovascular Research (DZHK), Munich (C. Kupatt, T.B.).ORCID 0000-0002-6545-2150
Christoph KuglerFaculty of Life Sciences, Laboratory of Macromolecular Cancer Therapeutics (MMCT), Department of Pharmaceutical Sciences, University of Vienna, Austria (C. Kugler, H.S., M.O.).ORCID 0000-0002-6503-7731
Haider SamiFaculty of Life Sciences, Laboratory of Macromolecular Cancer Therapeutics (MMCT), Department of Pharmaceutical Sciences, University of Vienna, Austria (C. Kugler, H.S., M.O.).ORCID 0000-0002-5777-3472
Manfred OgrisFaculty of Life Sciences, Laboratory of Macromolecular Cancer Therapeutics (MMCT), Department of Pharmaceutical Sciences, University of Vienna, Austria (C. Kugler, H.S., M.O.).ORCID 0000-0002-4576-6961
Kathrin A StilzInstitute of Cardiovascular Regeneration (L.S.T., T.L., S.F.G., A.F., M.M., K.A.S., J.P., M.M.-R., L.-M.K., L.Z., L.S., B.S., D.R.M., D.J., H.K., M.-T.K., E.G.S., G.L., W.T.A., S.C., S.D.), Goethe University, Frankfurt, Germany.ORCID 0000-0001-7194-3231
Josefine PanthelInstitute of Cardiovascular Regeneration (L.S.T., T.L., S.F.G., A.F., M.M., K.A.S., J.P., M.M.-R., L.-M.K., L.Z., L.S., B.S., D.R.M., D.J., H.K., M.-T.K., E.G.S., G.L., W.T.A., S.C., S.D.), Goethe University, Frankfurt, Germany.
Marion Muhly-ReinholzInstitute of Cardiovascular Regeneration (L.S.T., T.L., S.F.G., A.F., M.M., K.A.S., J.P., M.M.-R., L.-M.K., L.Z., L.S., B.S., D.R.M., D.J., H.K., M.-T.K., E.G.S., G.L., W.T.A., S.C., S.D.), Goethe University, Frankfurt, Germany.
Lisa-Maria KettenhausenInstitute of Cardiovascular Regeneration (L.S.T., T.L., S.F.G., A.F., M.M., K.A.S., J.P., M.M.-R., L.-M.K., L.Z., L.S., B.S., D.R.M., D.J., H.K., M.-T.K., E.G.S., G.L., W.T.A., S.C., S.D.), Goethe University, Frankfurt, Germany.
Lukas ZandersInstitute of Cardiovascular Regeneration (L.S.T., T.L., S.F.G., A.F., M.M., K.A.S., J.P., M.M.-R., L.-M.K., L.Z., L.S., B.S., D.R.M., D.J., H.K., M.-T.K., E.G.S., G.L., W.T.A., S.C., S.D.), Goethe University, Frankfurt, Germany.
Leonie SteinInstitute of Cardiovascular Regeneration (L.S.T., T.L., S.F.G., A.F., M.M., K.A.S., J.P., M.M.-R., L.-M.K., L.Z., L.S., B.S., D.R.M., D.J., H.K., M.-T.K., E.G.S., G.L., W.T.A., S.C., S.D.), Goethe University, Frankfurt, Germany.
Paul KiesslingMedical Faculty, Division of Nephrology and Clinical Immunology, RWTH Aachen University, Germany (P.K., C. Kuppe).ORCID 0000-0002-9794-9532
Florian SicklingerDepartment of Internal Medicine III, University of Heidelberg, Germany (F.S., F.L.).ORCID 0009-0004-6707-1695
Florian LeuschnerDepartment of Internal Medicine III, University of Heidelberg, Germany (F.S., F.L.).ORCID 0000-0003-1157-474X
Bianca SchuhmacherInstitute of Cardiovascular Regeneration (L.S.T., T.L., S.F.G., A.F., M.M., K.A.S., J.P., M.M.-R., L.-M.K., L.Z., L.S., B.S., D.R.M., D.J., H.K., M.-T.K., E.G.S., G.L., W.T.A., S.C., S.D.), Goethe University, Frankfurt, Germany.
Mauro SiragusaInstitute for Vascular Signalling, Centre for Molecular Medicine (M.S.), Goethe University, Frankfurt, Germany.ORCID 0000-0002-5862-5156
David Rodriguez MoralesInstitute of Cardiovascular Regeneration (L.S.T., T.L., S.F.G., A.F., M.M., K.A.S., J.P., M.M.-R., L.-M.K., L.Z., L.S., B.S., D.R.M., D.J., H.K., M.-T.K., E.G.S., G.L., W.T.A., S.C., S.D.), Goethe University, Frankfurt, Germany.ORCID 0000-0002-1819-6991
David JohnInstitute of Cardiovascular Regeneration (L.S.T., T.L., S.F.G., A.F., M.M., K.A.S., J.P., M.M.-R., L.-M.K., L.Z., L.S., B.S., D.R.M., D.J., H.K., M.-T.K., E.G.S., G.L., W.T.A., S.C., S.D.), Goethe University, Frankfurt, Germany.ORCID 0000-0003-3217-5449
Haris KujundzicInstitute of Cardiovascular Regeneration (L.S.T., T.L., S.F.G., A.F., M.M., K.A.S., J.P., M.M.-R., L.-M.K., L.Z., L.S., B.S., D.R.M., D.J., H.K., M.-T.K., E.G.S., G.L., W.T.A., S.C., S.D.), Goethe University, Frankfurt, Germany.
Minh-Thuy KatschkeInstitute of Cardiovascular Regeneration (L.S.T., T.L., S.F.G., A.F., M.M., K.A.S., J.P., M.M.-R., L.-M.K., L.Z., L.S., B.S., D.R.M., D.J., H.K., M.-T.K., E.G.S., G.L., W.T.A., S.C., S.D.), Goethe University, Frankfurt, Germany.
Emmanouil G SolomonidisInstitute of Cardiovascular Regeneration (L.S.T., T.L., S.F.G., A.F., M.M., K.A.S., J.P., M.M.-R., L.-M.K., L.Z., L.S., B.S., D.R.M., D.J., H.K., M.-T.K., E.G.S., G.L., W.T.A., S.C., S.D.), Goethe University, Frankfurt, Germany.ORCID 0000-0003-2536-4479
Guillermo LuxánInstitute of Cardiovascular Regeneration (L.S.T., T.L., S.F.G., A.F., M.M., K.A.S., J.P., M.M.-R., L.-M.K., L.Z., L.S., B.S., D.R.M., D.J., H.K., M.-T.K., E.G.S., G.L., W.T.A., S.C., S.D.), Goethe University, Frankfurt, Germany.ORCID 0000-0001-8350-8659
Stephanie HehlgansDepartment of Radiotherapy and Oncology (S. Hehlgans, F.R.), Goethe University, Frankfurt, Germany.ORCID 0000-0002-6816-3450
Franz RödelDepartment of Radiotherapy and Oncology (S. Hehlgans, F.R.), Goethe University, Frankfurt, Germany.
Christoph KuppeMedical Faculty, Division of Nephrology and Clinical Immunology, RWTH Aachen University, Germany (P.K., C. Kuppe).ORCID 0000-0003-4597-9833
Wesley T AbplanalpInstitute of Cardiovascular Regeneration (L.S.T., T.L., S.F.G., A.F., M.M., K.A.S., J.P., M.M.-R., L.-M.K., L.Z., L.S., B.S., D.R.M., D.J., H.K., M.-T.K., E.G.S., G.L., W.T.A., S.C., S.D.), Goethe University, Frankfurt, Germany.ORCID 0000-0001-5996-8997
Sebastian CremerInstitute of Cardiovascular Regeneration (L.S.T., T.L., S.F.G., A.F., M.M., K.A.S., J.P., M.M.-R., L.-M.K., L.Z., L.S., B.S., D.R.M., D.J., H.K., M.-T.K., E.G.S., G.L., W.T.A., S.C., S.D.), Goethe University, Frankfurt, Germany.
Stefanie DimmelerInstitute of Cardiovascular Regeneration (L.S.T., T.L., S.F.G., A.F., M.M., K.A.S., J.P., M.M.-R., L.-M.K., L.Z., L.S., B.S., D.R.M., D.J., H.K., M.-T.K., E.G.S., G.L., W.T.A., S.C., S.D.), Goethe University, Frankfurt, Germany.ORCID 0000-0002-1045-2436
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEndothelial cells (ECs) play pivotal roles in maintaining cardiac blood supply and regulating inflammation by acting as gatekeepers for immune cell activity. This study unveils a novel immunomodulatory function of cardiac ECs following myocardial infarction.
methodsWe used single-cell RNA sequencing and spatial transcriptomics to identify EC states after acute myocardial infarction in mice. Subsequently, we mimicked the cytokine environment that was predicted to induce EC activation in cell culture studies and confirmed the results in an endothelial-specific deletion mouse model.
resultsSingle-cell RNA sequencing analysis identified a transient myeloid
conclusionsThese findings provide insight into the role of ECs regulating adaptive immune responses following myocardial infarction, offering potential insights into therapeutic interventions for postinfarction immunomodulation.
Indexed as
Cell CommunicationEndothelial CellsMyocardial InfarctionT-LymphocytesAnimalsCells, CulturedCore Binding Factor Alpha 2 SubunitCytokinesDisease Models, AnimalMaleMiceMice, Inbred C57BLMice, KnockoutCore Binding Factor Alpha 2 SubunitCytokinesRunx1 protein, mouseendothelial cellsinfarctioninflammationischemiaT-lymphocytes
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