Evidence map›Paper›PMID 40735707›Full record

ArticleClinical case reports2025

Managing the Giant: A Novel Approach in Orthotopic Heart Transplantation With Extreme Left Atrial Enlargement.

Lorenzo Giovannico, Federica Mazzone, Giuseppe Fischetti, Domenico Parigino, Luca Savino, Tommaso Acquaviva, Aldo Domenico Milano, Tomaso Bottio

Abstract read
In one paragraph

Article in Clinical case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lorenzo GiovannicoCardiac Surgery Unit, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J) University of Bari Medical School Bari Italy.ORCID https://orcid.org/0000-0002-9583-1581
Federica MazzoneCardiac Surgery Unit, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J) University of Bari Medical School Bari Italy.
Giuseppe FischettiCardiac Surgery Unit, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J) University of Bari Medical School Bari Italy.
Domenico PariginoCardiac Surgery Unit, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J) University of Bari Medical School Bari Italy.
Luca SavinoCardiac Surgery Unit, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J) University of Bari Medical School Bari Italy.
Tommaso AcquavivaCardiac Surgery Unit, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J) University of Bari Medical School Bari Italy.
Aldo Domenico MilanoCardiac Surgery Unit, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J) University of Bari Medical School Bari Italy.
Tomaso BottioCardiac Surgery Unit, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J) University of Bari Medical School Bari Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This case report highlights an innovative surgical approach in orthotopic heart transplantation (OHT) for a patient with the largest recorded giant left atrium, measuring a biplanar volume of 1906 mL. The patient, a 63-year-old man with severe heart failure and a history of mitral and aortic valve replacements, presented with atrial fibrillation, moderate systolic dysfunction, and severe cardiomegaly. Despite optimized medical therapy, his condition warranted heart transplantation. The procedure involved a novel surgical technique utilizing Teflon reinforcement and a bovine pericardial patch to reconstruct the significantly enlarged left atrium. Postoperative outcomes were favorable, with no rejection episodes and resolution of pulmonary symptoms. This report underscores the challenges of atrial size mismatch in OHT and the necessity for tailored surgical strategies to address extreme anatomical variations. The successful outcome exemplifies the potential of customized approaches in complex heart transplant cases.

Indexed as

atrial reconstructionbovine pericardial patchgiant left atriumorthotopic heart transplantationsuperior vena cava syndrome

Identifiers

PMID40735707
PMCPMC12301168

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.