Evidence map›Paper›PMID 40735650›Full record

ArticleInfection and drug resistance2025

Successful Treatment of Mucormycosis and Azole-Resistant

Tingting Zhao, Yuan Fang, Qiuhui Wu, Minke Shi, Yueyan Ni, Ruyi Zou, Mengying Liu, Weiwei Wu, Xin Su

Abstract readCase Reports
In one paragraph

Article in Infection and drug resistance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Mixed InvasiveRespirology case reports · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tingting ZhaoDepartment of Respiratory and Critical Care Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, 210008, People's Republic of China.
Yuan FangDepartment of Respiratory and Critical Care Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, 210008, People's Republic of China.
Qiuhui WuDepartment of Pharmacy, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, 210008, People's Republic of China.
Minke ShiDepartment of Thoracic Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, 210008, People's Republic of China.
Yueyan NiDepartment of Respiratory and Critical Care Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, 210008, People's Republic of China.
Ruyi ZouDepartment of Respiratory and Critical Care Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, 210008, People's Republic of China.
Mengying LiuDepartment of Respiratory and Critical Care Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, 210008, People's Republic of China.
Weiwei WuDinfectome Inc., Nanjing, Jiansu, 210000, People's Republic of China.
Xin SuDepartment of Respiratory and Critical Care Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, 210008, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To report a case of coinfection with mucormycosis and azole-resistant Methods: A 52-year-old man who presented to our hospital with a 1-month history of fever accompanied by productive cough and sputum. He had type 2 diabetes with poor control of glucose level. Chest computed tomography (CT) showed rapidly progressive multiple cavities and consolidation in the lungs. Sputum culture showed azole-resistant Results: Following the initiation of high-dose posaconazole and liposomal amphotericin B, the patient's temperature normalized, and pulmonary exudates significantly improved. Therapeutic drug monitoring (TDM) showed that posaconazole trough concentrations were maintained at 3-4 mg/L without significant hepatic or renal toxicity. The main adverse effects observed were hypokalemia and anorexia. After 102 days of antifungal therapy, the patient underwent successful lobectomy, leading to complete resolution of symptoms. Conclusion: This case demonstrated the good efficacy and safety of high-dose posaconazole combined with liposomal amphotericin B in the treatment of azole-resistant

Indexed as

azole-resistant Aspergillus fumigatuscombination therapyhigh-dose posaconazoleinvasive pulmonary aspergillosismucormycosis

Identifiers

PMID40735650
PMCPMC12306537

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.