Evidence map›Paper›PMID 40735643›Full record

ReviewFrontiers in cell and developmental biology2025

Advances in the comprehensive mechanisms, diagnosis, and treatment of heatstroke-induced coagulopathy.

Chuhan Xiang, Ling Gao, Xuhui Liu, Jun Xiang, Bin Zhu, Shihui Fu, Jianhui Zhao, Qing Song

Abstract readReview
In one paragraph

Review in Frontiers in cell and developmental biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chuhan Xiang *Department of Cardiology, The 71st Group Army Hospital of People's Liberation Army, Xuzhou, Jiangsu, China.
Ling Gao *Department of Pharmacy, The 71st Group Army Hospital of People's Liberation Army, Xuzhou, Jiangsu, China.
Xuhui Liu *Neurology Department, The Second Hospital of Lanzhou University, Lanzhou, China.
Jun XiangDepartment of Cardiology, The 71st Group Army Hospital of People's Liberation Army, Xuzhou, Jiangsu, China.
Bin ZhuDepartment of Pharmacy, The 71st Group Army Hospital of People's Liberation Army, Xuzhou, Jiangsu, China.
Shihui FuDepartment of Cardiology, Hainan Hospital of Chinese People's Liberation Army General Hospital, Hainan Geriatric Disease Clinical Medical Research Center, Hainan Branch of China Geriatric Disease Clinical Research Center, Sanya, China.
Jianhui ZhaoChinese People's Liberation Army Heatstroke Prevention and Treatment Research Center, Sanya, Hainan, China.
Qing SongChinese People's Liberation Army Heatstroke Prevention and Treatment Research Center, Sanya, Hainan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heatstroke (HS) is a life-threatening condition that is precipitated by heat stress. The coagulation disorder that consequentially develops is termed heatstroke-induced coagulopathy (HIC). HIC typically presents as either hypocoagulopathy or hypercoagulopathy and is a principal complication that contributes to HS-associated mortality. There is no current consensus regarding HIC pathophysiology and specific pharmacological treatments. We review the diagnostic approaches, underlying mechanisms, and therapeutic interventions for HIC, with a particular emphasis on pharmacological treatments that include replacement therapy, anticoagulant therapy, traditional Chinese medicine, and novel therapies. The aim of this study is to enhance HIC awareness among clinicians and researchers and discuss the latest treatment strategy advancements to ultimately facilitate comprehensive HIC management and reduce its mortality rate.

Indexed as

anticoagulationdiagnostic criteriaheatstrokeheatstroke-induced coagulopathypathogenesissubstitute

Identifiers

PMID40735643
PMCPMC12303890

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.