Evidence map›Paper›PMID 40735601›Full record

ArticleJournal of diabetes and metabolic disorders2025

Novel role of NR1D1 and SLC7A5 in gestational diabetes mellitus: regulation of polyamine metabolism.

Zhiqi Wang, Guangjuan Fang, Yanjiao Yao, Jing Wang

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In one paragraph

Article in Journal of diabetes and metabolic disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Zhiqi WangDepartment of Obstetrics, The First Hospital of Lanzhou University, NO.1 Donggang West Road,Chengguan District, Lanzhou, Gansu 730000 China.
Guangjuan FangDepartment of Obstetrics, The First Hospital of Lanzhou University, NO.1 Donggang West Road,Chengguan District, Lanzhou, Gansu 730000 China.
Yanjiao YaoDepartment of Obstetrics, The First Hospital of Lanzhou University, NO.1 Donggang West Road,Chengguan District, Lanzhou, Gansu 730000 China.
Jing WangDepartment of Obstetrics, The First Hospital of Lanzhou University, NO.1 Donggang West Road,Chengguan District, Lanzhou, Gansu 730000 China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: A potential link exists between gestational diabetes mellitus (GDM) and polyamines, yet the mechanism of polyamine metabolism-related genes (PMRGs) in GDM remains elusive. This study aims to clarify the relationship between PMRGs and GDM. Methods: The study utilized GDM-related datasets (GSE203346, GSE154414) and PMRGs scores. Differential expression analysis on GSE203346 identified differentially expressed genes (DEGs), which were then stratified based on PMRGs scores. Then, differentially expressed PMRGs (DE-PMRGs) were screened between high and low scoring groups, intersecting with DEGs to select candidate genes. Hub genes were further identified using ML and validated. Gene set enrichment analysis (GSEA), regulatory network analysis, and drug prediction explored mechanisms and potential treatments. Finally, hub gene expression was verified by real-time reverse transcriptase-polymerase chain reaction (RT-qPCR). Results: Overall 22 candidate genes were obtained through the intersection of 465 DEGs and 71 DE-PMRGs. Afterwards, 2 hub genes ( Conclusions:

Indexed as

Differentially expressed genesGestational diabetes mellitusPolyamine metabolism-related genesRegulatory mechanism

Identifiers

PMID40735601
PMCPMC12301290

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.