Evidence map›Paper›PMID 40735472›Full record

ArticleMultiple sclerosis journal - experimental, translational and clinical

Enhanced cognitive outcomes with telehealth-based tDCS in multiple sclerosis: Results from a sham-controlled RCT.

Leigh Charvet, Judith Goldberg, Xiaochun Li, Pamela Best, Michael Shaw, Lana Zhovtis Ryerson, Josef Gutman, Marom Bikson, Giuseppina Pilloni, Lauren Krupp

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Multiple sclerosis journal - experimental, translational and clinical. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03838770 (Transcranial Direct Current Stimulation), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03838770 nacompletednot on this map

Transcranial Direct Current Stimulation (tDCS) for the Management of Multiple Sclerosis Related Fatigue

TypeinterventionalSponsorNYU Langone HealthRan2019 to 2021Enrolled122ConditionsMultiple SclerosisArmsActive tDCS, sham tDCS
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Leigh CharvetDepartment of Neurology, NYU Grossman School of Medicine, New York, NY, USA.ORCID https://orcid.org/0000-0003-4429-9713
Judith GoldbergDivision of Biostatistics, Department of Population Health, NYU Grossman School of Medicine, New York, NY, USA.
Xiaochun LiDivision of Biostatistics, Department of Population Health, NYU Grossman School of Medicine, New York, NY, USA.
Pamela BestDepartment of General Medicine, Stony Brook Medicine, Stony Brook, NY, USA.
Michael ShawDepartment of Psychology, Binghamton University, Binghamton, NY, USA.
Lana Zhovtis RyersonDepartment of Neurology, Hackensack Meridian Health, JSUMC, NJ, USA.
Josef GutmanDepartment of Neurology, NYU Grossman School of Medicine, New York, NY, USA.
Marom BiksonDepartment of Biomedical Engineering, City College of New York, New York, NY, USA.
Giuseppina PilloniDepartment of Neurology, NYU Grossman School of Medicine, New York, NY, USA.ORCID https://orcid.org/0000-0001-6226-5627
Lauren KruppDepartment of Neurology, NYU Grossman School of Medicine, New York, NY, USA.ORCID https://orcid.org/0000-0001-7003-807X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Cognitive impairment is common in multiple sclerosis (MS). Transcranial direct current stimulation (tDCS) combined with adaptive cognitive training (aCT) may improve clinical outcomes. Objective: To evaluate the effect of active vs. sham home-based tDCS + aCT on cognitive function. Methods: Participants with MS and fatigue, without depression or severe cognitive impairment, were randomized to complete 30 remotely supervised 20-minute sessions of active (2.0 mA) or sham tDCS targeting the left anodal dorsolateral prefrontal cortex, paired with aCT. Randomization was stratified by high (H) vs. low (L) EDSS. The Brief International Cognitive Assessment in MS (BICAMS) was administered at baseline and intervention end, with scores converted to demographics-adjusted Results: Out of 117 participants, 106 completed BICAMS assessments. Compliance was high; 92% completed >25 sessions. Mean change in BICAMS Conclusions: Active vs. sham tDCS + aCT resulted in significantly better cognitive outcomes, with the greatest benefit in those with high neurologic disability.CLINICALTRIALS.GOV; https://clinicaltrials.gov/study/NCT03838770; IDENTIFIER: NCT03838770.

Indexed as

brainHQCognitive traininghome-basedtDCStelemedicinetranscranial direct current stimulation

Identifiers

PMID40735472
PMCPMC12304595

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.