ATG16L1 promotes cell migration and invasion in high glucose-induced retinal capillary endothelial cells.

Xinxiao Gao, Pinxue Xie, Wen Feng, Jindong Han, Xiaobo Tan

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Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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5 authors.

Xinxiao Gao *Department of Ophthalmology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.

Pinxue Xie *Department of Ophthalmology, Xiangya Hospital, Central South University, Changsha, China.

Wen FengBeijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.

Jindong HanTianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China.

Xiaobo TanDepartment of Ophthalmology, The Affiliated Hospital of Chengde Medical University, Chengde, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Diabetic retinopathy (DR), a common chronic complication of diabetes, often results in irreversible visual dysfunction. This study investigated the mechanisms underlying the expression of ATG16L1, a potential biomarker of DR. Methods: We investigated the role of ATG16L1 in high glucose (HG)-induced retinal capillary endothelial cells (RCECs). Rat RCECs were cultured in normal glucose (NG) or HG medium with or without ATG16L1 transfection. Results: The mRNA and protein expression levels of ATG16L1 were significantly upregulated in RCECs exposed to HG medium. The migration ability and invasion rate of RCECs were significantly higher in the HG group than in the NG group but decreased markedly after transfection with ATG16L1 siRNA, compared with those in the control group ( Conclusion: ATG16L1 might be involved in the development of DR by promoting the migration of RCECs.

Indexed as

ATG16L1cell invasioncell migrationdiabetic retinopathyretinal capillary endothelial cells

Identifiers

PMID40735446

DOI10.3389/fmed.2025.1515936

PMCPMC12303877

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