Evidence map›Paper›PMID 40735274›Full record

ArticleNeuro-oncology advances

Molecular, histologic, and clinical characterization of methylation class pleomorphic xanthoastrocytoma: An analysis of 469 tumors.

Christopher H Dampier, Niharika Shah, Kristyn Galbraith, Azadeh Ebrahimi, Osorio Lopes Abath Neto, Zied Abdullaev, Sanda Alexandrescu, Felipe Andreiuolo, Terri Armstrong, Tiffany Baker and 50 more

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Article in Neuro-oncology advances. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

60 authors.

Christopher H DampierLaboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.ORCID https://orcid.org/0000-0003-3099-6462
Niharika ShahLaboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.
Kristyn GalbraithDepartment of Pathology, NYU Langone Health, New York, New York 10016, USA.
Azadeh EbrahimiInstitute for Neuropathology, Department of Pathology and Neuropathology, University of Tuebingen, Tuebingen, Germany.
Osorio Lopes Abath NetoDepartment of Pathology, University of Iowa, Iowa City, Iowa, USA.
Zied AbdullaevLaboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.
Sanda AlexandrescuDepartment of Pathology, Boston Children's Hospital, Boston, Massachusetts, USA.
Felipe AndreiuoloDepartment of Pathology, Instituto Estadual do Cerebro Paulo Niemeyer, Rio de Janeiro, Brazil.
Terri ArmstrongNeuro-Oncology Branch, National Cancer Institute and National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA.
Tiffany BakerDepartment of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.
Sahara CathcartDepartment of Pathology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Hye-Jung ChungLaboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.
Patrick J CiminoSurgical Neurology Branch, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA.ORCID https://orcid.org/0000-0003-0441-4502
Kyle S ConwayDepartment of Pathology, University of Michigan Health System, Ann Arbor, Michigan, USA.
Jennifer CotterDepartment of Pathology, Children's Hospital Los Angeles, Los Angeles, California, USA.
Felipe D'Almeida CostaDepartment of Pathology, AC Camargo Cancer Center, R. Prof. Antonio Prudente, Sao Paulo, Brazil.
Karen DazelleLaboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.
Nima EtminamDepartment of Neurosurgery, University Medical Center Mannheim, Mannheim, Germany.
Sima Esther FermanDepartment of Pediatric Oncology, Instituto Nacional de Cancer (INCA), Praca Cruz Vermelha, Rio de Janeiro, Brazil.
Igor FernandesLaboratorio Bacchi, R. Maj. Leonidas Cardoso, Botucatu, Brazil.
Christina K FerroneLaboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.
Ahmed GilaniDepartment of Pathology, Children's Hospital of Colorado, Aurora, Colorado, USA.
Mark GilbertNeuro-Oncology Branch, National Cancer Institute and National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA.
Jason GregoryDepartment of Pathology, Walter Reed National Military Medical Center, Bethesda, Maryland, USA.
Courtney KetchumLaboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.
Han Sung LeeDepartment of Pathology, University of California Davis, Sacramento, California, USA.
Ina LeeLaboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.
Maria Beatriz S LopesDepartment of Pathology, University of Virginia Health System, Charlottesville, Virginia, USA.
Qinwen MaoDepartment of Pathology, University of Utah, Salt Lake City, Utah, USA.ORCID https://orcid.org/0000-0001-7876-2046
Michael S MarshallDepartment of Pathology, Rush University Medical Center, Chicago, Illinois, USA.
Matthew McCordDepartment of Pathology, Northwestern University, Chicago, Illinois, USA.
Stewart G NeillDepartment of Pathology, Emory University School of Medicine, Atlanta, Georgia, USA.
Jeffrey J NirschlDepartment of Pathology, Stanford University, Stanford, California, USA.
Byram H OzerNeuro-Oncology Branch, National Cancer Institute and National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA.
Werner PaulusInstitute for Neuropathology, University Hospital Muenster, Muenster, Germany.
Marta Penas-PradoNeuro-Oncology Branch, National Cancer Institute and National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA.
Marco PrinzInstitute of Neuropathology, University of Freiburg, Faculty of Medicine, Freiburg, Germany.ORCID https://orcid.org/0000-0002-0349-1955
Peter PytelDepartment of Pathology, University of Chicago, Goldblatt Pavilion, Chicago, Illinois, USA.
Martha QuezadoLaboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.
Mark RaffeldLaboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.
Sharika RajanLaboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.
Miriam RatliffDepartment of Neurosurgery, University Medical Center Mannheim, Mannheim, Germany.ORCID https://orcid.org/0000-0002-9464-6544
Guido ReifenbergerInstitute for Neuropathology, Heinrich Heine University, Medical Faculty and University Hospital Duesseldorf, Duesseldorf, Germany.
Lorraina RobinsonDepartment of Pathology, University of Utah, Salt Lake City, Utah, USA.ORCID https://orcid.org/0009-0005-1098-4909
Jens SchittenhelmInstitute for Neuropathology, Department of Pathology and Neuropathology, University of Tuebingen, Tuebingen, Germany.ORCID https://orcid.org/0000-0002-9168-6209
Daniel SchrimpfDepartment of Neuropathology, Institute of Pathology, University Heidelberg and Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Omkar SinghLaboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.
Christian ThomasInstitute for Neuropathology, University Hospital Muenster, Muenster, Germany.ORCID https://orcid.org/0000-0002-6642-7774
Diana ThomasDepartment of Pathology, Nationwide Children's Hospital, Columbus, Ohio, USA.
Jaiyeola Thomas-OgunniyiDepartment of Pathology and Laboratory Medicine, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, Texas , USA.
Angus TolandDepartment of Pathology, Children's Hospital of Colorado, Aurora, Colorado, USA.
Rust TurakulovLaboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.
Rachael VaubelDepartment of Pathology, Mayo Clinic Laboratories, Rochester, Minnesota, USA.ORCID https://orcid.org/0000-0001-8842-5975
Nitin WadhwaniDepartment of Pathology, Lurie Children's Hospital, Chicago, Illinois, USA.
Jing WuNeuro-Oncology Branch, National Cancer Institute and National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA.ORCID https://orcid.org/0000-0002-1686-9646
Caterina GianniniDepartment of Pathology, Mayo Clinic Laboratories, Rochester, Minnesota, USA.ORCID https://orcid.org/0000-0003-2757-6782
Matija SnuderlDepartment of Pathology, NYU Langone Health, New York, New York 10016, USA.
Sebastian BrandnerDivision of Neuropathology, The National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, London, UK.ORCID https://orcid.org/0000-0002-8635-7195
Andreas von DeimlingDepartment of Neuropathology, Institute of Pathology, University Heidelberg and Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID https://orcid.org/0000-0002-5863-540X
Kenneth AldapeLaboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.ORCID https://orcid.org/0000-0001-5119-7550

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Methylation class pleomorphic xanthoastrocytoma (mcPXA) comprises tumors with the DNA methylation signature of classical PXA but with a wider histologic spectrum, including overlap with glioblastoma (GBM). Methods: To clarify the histologic and molecular scope of mcPXA and characterize its clinical behavior, a cohort of 469 tumor samples from 458 patients matching to mcPXA by the DKFZ classifier (v12.6 score ≥0.85) was interrogated. Results: Patient median age was 23 years (range 1-73 years) with a female predominance (259 female/199 male). Conclusion: Tumors in mcPXA share molecular characteristics with histologically defined PXA, and high-grade histologic features can help predict their clinical behavior. The use of an epigenetic classification of PXA reveals that this group of tumors is more common than previously appreciated and warrants in-depth study to identify efficacious therapeutic options.

Indexed as

BRAF p.V600ECDKN2A/B deletionDNA methylation classificationepithelioid glioblastomapleomorphic xanthoastrocytoma

Identifiers

PMID40735274
PMCPMC12305539

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