Evidence map›Paper›PMID 40735265›Full record

ArticleBrain communications2025

Whole-brain functional connectivity predicts regional tau PET in preclinical Alzheimer's disease.

Hamid Abuwarda, Anne Trainer, Corey Horien, Xilin Shen, Sophia Moret, Suyeon Ju, R Todd Constable, Carolyn Fredericks

Abstract read
In one paragraph

Article in Brain communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Hamid AbuwardaDepartment of Neurology, Yale School of Medicine, New Haven, CT 06519, USA.ORCID https://orcid.org/0000-0001-8185-0397
Anne TrainerDepartment of Neurology, Yale School of Medicine, New Haven, CT 06519, USA.
Corey HorienInterdepartmental Neuroscience Program, Yale School of Medicine, New Haven, CT 06519, USA.
Xilin ShenDepartment of Biomedical Engineering, Yale School of Medicine, New Haven, CT 06519, USA.
Sophia MoretDepartment of Neurology, Yale School of Medicine, New Haven, CT 06519, USA.
Suyeon JuDepartment of Neurology, Yale School of Medicine, New Haven, CT 06519, USA.
R Todd ConstableInterdepartmental Neuroscience Program, Yale School of Medicine, New Haven, CT 06519, USA.
Carolyn FredericksDepartment of Neurology, Yale School of Medicine, New Haven, CT 06519, USA.ORCID https://orcid.org/0000-0002-7051-6382

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Yale Alzheimer Disease Research CenterP30AG066508 · NIA · YALE UNIVERSITY · PI Heather Gwynn Allore · 2020 to 2026
$30.2M
MAPPING THE HUMAN CONNECTOME DURING TYPICAL AGINGU01AG052564 · NIA · WASHINGTON UNIVERSITY · PI SALAT, DAVID H, TERPSTRA, MELISSA J · 2016 to 2020
$18.9M
Multimodal Delineation of Neurodegenerative MechanismsT32NS131190 · NINDS · YALE UNIVERSITY · PI Sreeganga S Chandra, STEPHEN M STRITTMATTER · 2023 to 2026
$1.1M
Thalamic Contributions to Functional Network Abnormalities in Alzheimer's DiseaseK23AG059919 · NIA · YALE UNIVERSITY · PI FREDERICKS, CAROLYN ANNE · 2019 to 2023
$1.0M
NCATS NIH HHS UL1 TR001863NIA NIH HHS K23 AG059919NIA NIH HHS P30 AG066508NIA NIH HHS U01 AG024904NIA NIH HHS U01 AG052564NINDS NIH HHS T32 NS131190
6 · The paper itself

Abstract

Preclinical Alzheimer's disease, characterized by the abnormal accumulation of amyloid-β prior to cognitive symptoms, presents a critical opportunity for early intervention. Past work has described functional connectivity (FC) changes in preclinical Alzheimer's disease, yet the predictive

Indexed as

asymptomaticdementiamachine learningmultimodalneurodegeneration

Identifiers

PMID40735265
PMCPMC12305425

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.