ArticleHealth science reports2025
Left Ventricular Function and Echocardiographic Parameters in Patients Undergoing Chemotherapy With 5-Fluorouracil, Anthracycline, Taxotere, and Herceptin: Prospective Cohort Study.
Article in Health science reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Investigation of potential sex-based differences in trastuzumab-induced chronic cardiotoxicity in a rat model.Frontiers in pharmacology · 2026Article
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Authors and funding
3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Background: Despite recent progress in cancer treatment, the side effects of treatment are recognized as a major source of mortality and morbidity in patients. This study was developed and conducted to evaluate the influence of chemotherapy on left ventricular function and echocardiographic and electrocardiographic parameters in patients undergoing chemotherapy with 5-fluorouracil, anthracycline, taxotere, and herceptin. Methods: This study is a prospective cohort study on patients diagnosed with cancer. After reviewing the inclusion and exclusion criteria, patients referred for treatment with 5-fluorouracil, anthracycline, taxotere, or herceptin were randomly divided into study groups. Echocardiographic and electrocardiographic parameters such as left ventricular ejection fraction (LVEF), LV end systolic dimension (LVESD), LV end diastolic dimension (LVEDD), tricuspid annular plane systolic excursion (TAPSE), Mid RV diameter, RA volume, QRS duration, and QTc were evaluated at the beginning of the study and 6 months after starting treatment. Subsequently, the measurements were compared and analyzed. Results: Overall, 80 patients undergoing chemotherapy with 5-fluorouracil, anthracycline, taxotere, or herceptin were included in this study. LVEF and TAPSE were significantly lower after 6 months in patients treated with anthracycline and herceptin, while LV end diastolic dimension and LV end systolic dimension were higher significantly ( Conclusion: The findings indicated that chemotherapy with anthracycline and herceptin is significantly linked to altered left ventricular function and echocardiographic measures such as LV end diastolic dimension, LV end systolic dimension, and TAPSE. However, future research with more extensive follow-up are recommended to investigate cardiac side effects in these patients.
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