ReviewHealth science reports2025
The Effect of Intravenous Albumin Administration Before Exchange Transfusion in Infants With Hyperbilirubinemia: A Meta-Analysis.
Review in Health science reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Aims: This meta-analysis aimed to assess the impact of intravenous albumin administration before exchange transfusion in infants diagnosed with hyperbilirubinemia. Methods: A comprehensive search was conducted in multiple electronic databases, including PubMed (Medline), Scopus, Embase, Web of Science, Cochrane Library, and ClinicalTrials.gov, using relevant keywords. The quality of the included randomized controlled trials (RCTs) was evaluated using the Cochrane Risk of Bias tool. Statistical analyses were performed using STATA (Version 18) and RevMan (Version 5). Results: Four RCTs met the inclusion criteria. Pooled analysis indicated a nonsignificant reduction in total bilirubin levels following intravenous albumin administration (SMD: -2.19; 95% CI: -4.79 to 0.41; Conclusion: While intravenous albumin administration before exchange transfusion did not show a statistically significant effect on total bilirubin levels overall, a potential bilirubin-lowering effect was observed when measured at later time points. Moreover, albumin significantly reduced the duration of phototherapy. These findings suggest potential clinical benefit, though further high-quality RCTs are warranted.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.