Evidence map›Paper›PMID 40735244›Full record

ArticleJournal of hand and microsurgery2025

Cold intolerance following microsurgical replantation of finger amputations: A retrospective cohort study.

Makoto Shiraishi, Mitsunaga Narushima, Chihena Hansini Banda, Yuta Moriwaki, Satoshi Miyamoto, Yuri Miyazaki, Mayu Okuyama, Kirito Kojima, Chizuki Kondo, Kosuke Yamagata and 6 more

Abstract read
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In one paragraph

Article in Journal of hand and microsurgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Makoto ShiraishiDepartment of Plastic and Reconstructive Surgery, Graduate School of Medicine, Mie University, Tsu, Japan.
Mitsunaga NarushimaDepartment of Plastic and Reconstructive Surgery, Graduate School of Medicine, Mie University, Tsu, Japan.
Chihena Hansini BandaDepartment of Plastic and Reconstructive Surgery, Graduate School of Medicine, Mie University, Tsu, Japan.
Yuta MoriwakiDepartment of Plastic and Reconstructive Surgery, The University of Tokyo Hospital, Tokyo, Japan.
Satoshi MiyamotoDepartment of Plastic and Reconstructive Surgery, Graduate School of Medicine, Mie University, Tsu, Japan.
Yuri MiyazakiDepartment of Plastic and Reconstructive Surgery, Graduate School of Medicine, Mie University, Tsu, Japan.
Mayu OkuyamaDepartment of Plastic and Reconstructive Surgery, Graduate School of Medicine, Mie University, Tsu, Japan.
Kirito KojimaDepartment of Plastic and Reconstructive Surgery, Graduate School of Medicine, Mie University, Tsu, Japan.
Chizuki KondoDepartment of Plastic and Reconstructive Surgery, Graduate School of Medicine, Mie University, Tsu, Japan.
Kosuke YamagataDepartment of Plastic and Reconstructive Surgery, Graduate School of Medicine, Mie University, Tsu, Japan.
Kohei MitsuiDepartment of Plastic and Reconstructive Surgery, Graduate School of Medicine, Mie University, Tsu, Japan.
Kohei HashimotoDepartment of Plastic and Reconstructive Surgery, Graduate School of Medicine, Mie University, Tsu, Japan.
Kento HosomiDepartment of Plastic and Reconstructive Surgery, Graduate School of Medicine, Mie University, Tsu, Japan.
Ryohei IshiuraDepartment of Plastic and Reconstructive Surgery, Graduate School of Medicine, Mie University, Tsu, Japan.
Masakazu KuritaDepartment of Plastic and Reconstructive Surgery, The University of Tokyo Hospital, Tokyo, Japan.
Isao KoshimaInternational Center for Lymphedema, Hiroshima University Hospital, Hiroshima, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Cold intolerance following finger amputation is a major postoperative complication. Although current evidence suggests decreased blood flow to digital peripheral vessels may be associated with cold intolerance, the underlying mechanism remains controversial. This study aimed to investigate the relationship between skin perfusion in affected fingers and the presence of cold intolerance. Methods: A retrospective cohort study was conducted to evaluate patients who underwent finger replantation at two centers between 2008 and 2020. Demographic data were collected, and at least one of the following evaluative methods was used: the Semmes-Weinstein monofilament test (SW test), moving two-point discrimination (M2PD), contrast-enhanced computed tomography, or thermography. Results: A total of 41 amputated fingers in 20 patients were assessed, with a mean follow-up period of 18.7 ± 12.1 months. Most injuries were located in Tamai zone 4 (n = 18, 43.9 %), followed by zone 1 (n = 9, 22.0 %), zone 2 (n = 9, 22.0 %), and zone 3 (n = 5, 12.2 %). The most common injury type was crush (n = 24, 58.5 %), followed by guillotine (n = 13, 31.7 %) and crush-avulsion (n = 4, 9.7 %). A significant difference was observed in the SW test (p = .047) and average vessel diameter (p = .047) between patients with and without cold intolerance. Conclusions: Narrowed blood vessels and impaired SW test scores are associated with cold intolerance after finger replantation. Nerve injury may potentially contribute to abnormal vasoconstriction. Further studies are needed to elucidate the underlying mechanisms of cold intolerance.

Indexed as

Cold intoleranceDigital amputationDigital replantationSemmes–Weinstein monofilament testSkin blood flow

Identifiers

PMID40735244
PMCPMC12301776

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.