ArticleJGH open : an open access journal of gastroenterology and hepatology2025
Efficacy and Safety of 10-Day Minocycline Twice Daily in Bismuth-Containing Quadruple Therapy as the First-Line Treatment of
Article in JGH open : an open access journal of gastroenterology and hepatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy and safety of antibiotic regimens forFrontiers in medicine · 2026Pooled it
- Repurposing minocycline as an added-on treatment for ulcerative colitis patients on mesalamine: a randomized clinical pilot study.Naunyn-Schmiedeberg's archives of pharmacology · 2026Trial
- Minocycline-containing therapy inTherapeutic advances in gastroenterology · 2026Review
- Efficacy and Safety of 10-Day Minocycline Twice Daily in Bismuth-Containing Quadruple Therapy as the First-Line Treatment ofJGH open : an open access journal of gastroenterology and hepatology · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Tetracycline has limited clinical application in Methods: In this prospective trial, treatment-naïve adults with Results: A total of 133 patients were included in the study. All of the patients completed the course of medication. We found that 10-day minocycline-amoxicillin quadruple therapy achieved an eradication rate of 83.5% (111/133, 95% CI 80.3%-86.7%) in intention-to-treat analysis and 90.2% (111/123, 95% CI 87.6%-92.8%) in per-protocol analysis. The treatment-emergent adverse events (TEAEs) were 15% (20/133), with the most common adverse event being dizziness (14/133, 10.5%). No severe adverse event was observed. Conclusions: Ten-day minocycline-amoxicillin twice daily in bismuth-containing quadruple therapy appears to be effective and safe for naïve
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.