SynthesisFrontiers in neurology2025
Salvage treatment strategies for refractory sudden sensorineural hearing loss-a comprehensive review and meta-analysis with practical recommendations.
Synthesis in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Rimegepant for vestibular and cochlear symptoms associated with vertigo in a real-world retrospective study.iScience · 2026Article
- Stellate Ganglion Block Combined with Hyperbaric Oxygen Therapy for Sudden Sensorineural Hearing Loss: A Retrospective Three-Arm Study.Life (Basel, Switzerland) · 2026Article
- Clinical effectiveness of salvage intratympanic corticosteroids for idiopathic sudden sensorineural hearing loss: a real-world observational series.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Efficacy of multimodal therapy for sudden sensorineural hearing loss: a propensity score-matched analysis of 1632 patients.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Optimal Timing of Intratympanic Corticosteroid Therapy for Idiopathic Sudden Sensorineural Hearing Loss: A Mini-Review.Medeniyet medical journal · 2026Article
- Efficacy evaluation and clinical value exploration of secondary inpatient treatment for total deafness-type SSNHL: a single-center prospective study.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Sudden sensorineural hearing loss (SSNHL) affects up to 27 per 100,000 people annually, with more than half not regaining full hearing after following standard therapy. Identifying effective salvage treatments for refractory cases is critical to improve outcomes and reduce long-term auditory disability. This systematic review aims to assess the effectiveness of current salvage treatments for SSNHL unresponsive to first-line systemic corticosteroid therapy, and to develop an evidence-based treatment algorithm. Methods: A comprehensive search of PubMed, Embase, and Cochrane Library was performed for English language articles published between January 2010 and April 2025. Studies eligible for inclusion were clinical trials and large case series that evaluated salvage interventions in patients with SSNHL who were unresponsive to systemic therapy. Risk of bias was assessed using the risk of bias in non-randomized studies of interventions (ROBINS-I) tool. Results: A total of 41 articles met the inclusion criteria. Intratympanic steroids (ITS), including methylprednisolone and dexamethasone, showed consistent effectiveness, with methylprednisolone achieving better results ( Conclusion: ITS and HY, especially when combined, are the most effective salvage therapies for refractory SSNHL. Methylprednisolone may offer better outcomes than dexamethasone, and early intervention continues to be a crucial prognostic factor. CIST showed promising potential in reducing cortical maladaptation to sound deprivation. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD42025645069, Identifier, CRD42025645069.
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