Evidence map›Paper›PMID 40734754›Full record

ArticleHeart rhythm O22025

Rhythm control benefits left ventricular function compared with rate control in patients with atrial fibrillation: A computational study.

Rosie K Barrows, Christoph M Augustin, Matthias A F Gsell, Caroline H Roney, José A Solís Lemus, Hao Xu, Alistair A Young, Ronak Rajani, John Whitaker, Edward J Vigmond and 4 more

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Article in Heart rhythm O2, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Rosie K BarrowsSchool of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom.
Christoph M AugustinGottfried Schatz Research Center, Division of Medical Physics and Biophysics, Medical University of Graz, Graz, Austria.
Matthias A F GsellGottfried Schatz Research Center, Division of Medical Physics and Biophysics, Medical University of Graz, Graz, Austria.
Caroline H RoneySchool of Engineering and Materials Science, Queen Mary University of London, London, United Kingdom.
José A Solís LemusNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Hao XuSchool of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom.
Alistair A YoungSchool of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom.
Ronak RajaniSchool of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom.
John WhitakerSchool of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom.
Edward J VigmondLiryc Heart Rhythm Disease Institute, Fondation Bordeaux University, Pessac-Bordeaux, France.
Martin J BishopSchool of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom.
Gernot PlankGottfried Schatz Research Center, Division of Medical Physics and Biophysics, Medical University of Graz, Graz, Austria.
Marina StrocchiNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Steven A NiedererNational Heart and Lung Institute, Imperial College London, London, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Atrial fibrillation (AF) alters heart rate, rhythm regularity, and atrial contraction, which may contribute to an increased risk of heart failure. Although rate and rhythm control target different aspects of these disturbances, their specific effects on left ventricular (LV) function remain unclear. Objective: The purpose of this study was to predict the independent and combined contribution of heart rate, rhythm regularity, and atrial contraction to LV function in patients with AF. Methods: We predicted LV ejection fraction (EF) and stroke volume (SV) in 10 whole-heart patient-specific models of patients with AF while varying heart rate, rhythm regularity, and effectiveness of atrial contraction.AF was modeled as a fast, irregular heart rate with no atrial contraction. Pharmacologic and paced rate control were modeled as a slow irregular and regular heart rate without atrial contraction, respectively, whereas rhythm control had a slow, regular heart rate with atrial contraction. Results: Rhythm control resulted in a greater improvement than pharmacological rate control in LVEF compared with AF (+5.1% ± 0.4% vs +2.8% ± 0.3%, Conclusion: Rhythm control provides superior improvements in LV function compared with rate control. However, restoring sinus rhythm may yield limited benefits to LV function when atrial contraction is ineffective or when heart rate is irregular.

Indexed as

Atrial fibrillationCardiac modelingElectromechanics modelingIn-silico trialRate controlRhythm control

Identifiers

PMID40734754
PMCPMC12302171

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