ArticlePublic health challenges2025
In Vitro Fertilization in Africa: Mild Versus Conventional Antagonist Ovarian Stimulation Protocols in Expected Normal Responders Undergoing IVF/ICSI: A Cohort Study From Ethiopia.
Article in Public health challenges, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Though infertility remains a global public health problem, it stands as a unique challenge in Sub-Saharan Africa, with either no or limited in vitro fertilization (IVF) service in most countries located in it. This study aimed to compare the efficacy of mild stimulation with conventional GnRH antagonist ovarian stimulation in patients with expected normal responders at a public IVF center in Ethiopia. Methods: A retrospective cohort study was conducted at Center for Fertility and Reproductive Medicine in Ethiopia. The primary outcomes were biochemical pregnancy rate, clinical pregnancy rate, and mature (M2) oocyte retrieval rate. Data were collected retrospectively by reviewing medical records of patients. SPSS version 26 was used to analyze the data. Mann-Whitney Results: Five hundred infertile women (age ≤39) undergoing their first IVF cycle. A total of 150 women exposed to mild stimulation group and 350 women exposed to conventional or antagonist IVF-group). The biochemical pregnancy was higher in MS-IVF, which is 35.3% and 28.6% in conventional (antagonist) IVF group, Conclusions: Compared to conventional antagonist IVF, MS-IVF has a higher biochemical pregnancy and lower risk of multiple pregnancy with comparative rates of clinical pregnancy, OHSS, and mature oocyte (M2).
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