Evidence map›Paper›PMID 40734688›Full record

ArticleInorganic chemistry frontiers2024

Understanding Structural Isomerism in Organoiridium Picolinamidate Complexes and its Consequences on Reactivity and Biological Properties.

Hieu D Nguyen, Croix J Laconsay, Rahul D Jana, Tuhin Ganguly, Sally T Hoang, Kanika Kaushal, Judy I Wu, Loi H Do

Abstract read
In one paragraph

Article in Inorganic chemistry frontiers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Selective Iridium-Catalyzed Reductive Amination Inside Living Cells.Journal of the American Chemical Society · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hieu D NguyenDepartment of Chemistry, University of Houston, 4800 Calhoun Rd., Houston, Texas, 77204, United States.
Croix J LaconsayDepartment of Chemistry, University of Houston, 4800 Calhoun Rd., Houston, Texas, 77204, United States.
Rahul D JanaDepartment of Chemistry, University of Houston, 4800 Calhoun Rd., Houston, Texas, 77204, United States.
Tuhin GangulyDepartment of Chemistry, University of Houston, 4800 Calhoun Rd., Houston, Texas, 77204, United States.
Sally T HoangDepartment of Chemistry, University of Houston, 4800 Calhoun Rd., Houston, Texas, 77204, United States.
Kanika KaushalDepartment of Chemistry, University of Houston, 4800 Calhoun Rd., Houston, Texas, 77204, United States.
Judy I WuDepartment of Chemistry, University of Houston, 4800 Calhoun Rd., Houston, Texas, 77204, United States.
Loi H DoDepartment of Chemistry, University of Houston, 4800 Calhoun Rd., Houston, Texas, 77204, United States.

Funding

Unlocking Biologically-Relevant Opportunities Through Applications of Excited-State Aromaticity and AntiaromaticityR35GM133548 · NIGMS · UNIVERSITY OF HOUSTON · PI WU, JUDY I-CHIA · 2019 to 2025
$3.8M
Development of Transfer Hydrogenation Small-Molecule Intracellular Metal Catalysts (SIMCats) and their Application Toward Toxic Aldehyde RemediationR01GM129276 · NIGMS · UNIVERSITY OF HOUSTON · PI DO, LOI HUNG · 2020 to 2024
$1.5M
NIGMS NIH HHS R01 GM129276NIGMS NIH HHS R35 GM133548
6 · The paper itself

Abstract

Organoiridium picolinamidate complexes are promising for intracellular applications because of their biocompatibility, activity in living systems, and ease of derivatization. To shield their metal centers from inhibition by biological nucleophiles (e.g., glutathione), attempts were made to increase the steric bulk of the supporting

Identifiers

PMID40734688
PMCPMC12302936

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.